Cruciforms occur when inverted repeat sequences in double-stranded DNA adopt intra-
strand hairpins on opposing strands. Biophysical and molecular studies of these structures …

Genetic mutation, which provides the raw material for evolutionary adaptation, is largely a
stochastic force. However, there is ample evidence showing that mutations can also exhibit …

Gene-strand bias is a characteristic feature of bacterial genome organization wherein genes
are preferentially encoded on the leading strand of replication, promoting co-orientation of …

Plastids, similar to mitochondria, are organelles of endosymbiotic origin, which retained their
vestigial genomes (ptDNA). Their unique architecture, commonly referred to as the …

Reprogramming organisms for large-scale bioproduction counters their evolutionary
objectives of fast growth and often leads to mutational collapse of the engineered production …

SARS-CoV-2 is an intensively investigated virus from the order Nidovirales (Coronaviridae
family) that causes COVID-19 disease in humans. Through enormous scientific effort …

We sequenced maxicircles from T. cruzi strains representative of the species evolutionary
diversity by using long-read sequencing, which allowed us to uncollapse their repetitive …

Ribonucleic acid (RNA) sequences can be viewed as an ordered list of symbols
representing the component nucleobases of the RNA sequence also known as its primary …

Inverted repeats are common DNA elements, but they rarely overlap with protein-coding
sequences due to the ensuing conflict with the structure and function of the encoded protein …

DNA polymerase template switching between short, non-identical inverted repeats (IRs) is a
genetic mechanism that leads to the homogenization of IR arms and to IR spacer inversion …