Propofol (2, 6-diisopropylphenol) is a potent intravenous hypnotic agent which is widely
used for the induction and maintenance of anesthesia and for sedation in the intensive care …

General anesthetics threaten cardiovascular stability by causing changes in cardiac
function, vascular reactivity, and cardiovascular reflexes and significantly alter distribution of …

BACKGROUND: Propofol causes hypotension due to relaxation of vascular smooth muscle
cells through its direct or indirect vasodilator effects. Perivascular adipose tissue (PVAT) and …

We tested the antiplatelet effect described for propofol in vitro in surgical patients. Platelet
aggregation induced by adenosine diphosphate, collagen, and arachidonic acid was tested …

There has been an explosive increase in the amount of interesting information about the
physiologic and pathophysiologic roles of nitric oxide in cardiovascular, nervous, and …

Background. The commercial propofol preparation in an intralipid solution causes marked
vasodilatation. Both propofol and its solvent seem to stimulate the nitric oxide (NO) pathway …

Objective: To test propofol and the solvent of propofol on leukocyte function in the presence
of endothelial cell monolayers. The interactions of leukocytes with endothelial cells play a …

From the* 1st Department of Cardiac Surgery and† Department of Cardiac Anesthesia and
Postoperative Intensive Care, Medical University of Silesia, Katowice, Poland. Address …

Objective To evaluate the cardiovascular effects of intravenous propofol in rabbits. Study
design Randomized, prospective, experimental study. Animals Thirty-one female New …

Objectives The aim of this study was to investigate the vascular effects and mechanisms of
propofol in the human internal mammary artery (IMA). Design In vitro experimental study …