The process of apoptosis is essential for maintaining the physiologic balance between cell
death and cell growth. This complex process is executed by two major pathways that …

Apoptosis, an important form of programmed cell death (PCD), is a tightly regulated cellular
process to eliminate unwanted or damaged cells. Resistance of apoptosis is a hallmark of …

We have recently reported a series of Lys-covalent agents targeting the BIR3 domain of the
X-linked inhibitor of apoptosis protein (XIAP) using a benzamide-sulfonyl fluoride warhead …

We have recently reported on the use of aryl-fluorosulfates in designing water-and plasma-
stable agents that covalently target Lys, Tyr, or His residues in the BIR3 domain of the …

Triple negative breast cancer (TNBC) patients have high risk of recurrence and metastasis,
and current treatment options remain limited. Cancer stem-like cells (CSCs) have been …

Affinity selection screening of macrocycle libraries derived from DNA-programmed chemistry
identified XIAP BIR2 and BIR3 domain inhibitors that displace bound pro-apoptotic …

The poor prognosis of ovarian cancer (it is the leading cause of death from gynecological
cancers) is mainly due to the acquisition of resistance to carboplatin. Among the possible …

We have recently investigated the reactivity of aryl-fluorosulfates as warheads to form
covalent adducts with Lys, Tyr, and His residues. However, the rate of reaction of aryl …

Abstract The Inhibitor of Apoptosis proteins (IAPs) are a family of proteins that are mainly
known for their anti-apoptotic activity and ability to directly bind and inhibit caspases. Recent …

Recently we reported that rapid determination of enthalpy of binding can be achieved for a
large number of congeneric agents or in combinatorial libraries fairly efficiently. We show …