The increasing number of people with dementia globally illustrates the urgent need to
reduce dementia's scale and impact. Lifetime social participation may affect dementia risk by …

Aging is characterized by the accumulation of damage to macromolecules and cell
architecture that triggers a proinflammatory state in blood and solid tissues, termed …

A diverse set of biological processes have been implicated in the pathophysiology of
Alzheimer's disease (AD) and related dementias. However, there is limited understanding of …

The advent of proteomics offers an unprecedented opportunity to predict dementia onset.
We examined this in data from 52,645 adults without dementia in the UK Biobank, with 1,417 …

SomaScan is a high-throughput, aptamer-based proteomics assay designed for the
simultaneous measurement of thousands of proteins with a broad range of endogenous …

Robust and accessible biomarkers that can capture the heterogeneity of Alzheimer's
disease and its diverse pathological processes are urgently needed. Here, we undertook an …

Developing a single-domain assay to identify individuals at high risk of future events is a
priority for multi-disease and mortality prevention. By training a neural network, we …

Peripheral inflammation, defined as inflammation that occurs outside the central nervous
system, is an age-related phenomenon that has been identified as a risk factor for …

Introduction Biological fluids are routine samples for diagnostic testing and monitoring.
Blood samples are typically measured because of their moderate invasive collection and …

A deeper understanding of the molecular processes underlying late-onset Alzheimer's
disease (LOAD) could aid in biomarker and drug target discovery. Using high-throughput …