The pathogenesis of lupus nephritis
Lupus nephritis is an immune complex GN that develops as a frequent complication of SLE.
The pathogenesis of lupus nephritis involves a variety of pathogenic mechanisms. The …
The pathogenesis of lupus nephritis involves a variety of pathogenic mechanisms. The …
Autoantibodies in systemic autoimmune diseases: specificity and pathogenicity
J Suurmond, B Diamond - The Journal of clinical …, 2015 - Am Soc Clin Investig
In this Review we focus on the initiation of autoantibody production and autoantibody
pathogenicity, with a special emphasis on the targeted antigens. Release of intracellular …
pathogenicity, with a special emphasis on the targeted antigens. Release of intracellular …
Anti-double stranded DNA antibodies: origin, pathogenicity, and targeted therapies
X Wang, Y Xia - Frontiers in immunology, 2019 - frontiersin.org
Systemic lupus erythematosus (SLE) is characterized by high-titer serological
autoantibodies, including antibodies that bind to double-stranded DNA (dsDNA). The origin …
autoantibodies, including antibodies that bind to double-stranded DNA (dsDNA). The origin …
Beyond tissue injury—damage-associated molecular patterns, Toll-like receptors, and inflammasomes also drive regeneration and fibrosis
HJ Anders, L Schaefer - Journal of the American Society of …, 2014 - journals.lww.com
Tissue injury initiates an inflammatory response through the actions of immunostimulatory
molecules referred to as damage-associated molecular patterns (DAMPs). DAMPs …
molecules referred to as damage-associated molecular patterns (DAMPs). DAMPs …
Lupus nephritis: a critical review
AT Borchers, N Leibushor, SM Naguwa… - Autoimmunity …, 2012 - Elsevier
Lupus nephritis remains one of the most severe manifestations of systemic lupus
erythematosus associated with considerable morbidity and mortality. A better understanding …
erythematosus associated with considerable morbidity and mortality. A better understanding …
Mechanisms of tissue injury in lupus nephritis
TK Nowling, GS Gilkeson - Arthritis research & therapy, 2011 - Springer
Systemic lupus erythematosus is a prototypic autoimmune disease characterized by
autoantibody production and immune complex formation/deposition in target organs such as …
autoantibody production and immune complex formation/deposition in target organs such as …
Mechanisms of kidney injury in lupus nephritis–the role of anti-dsDNA antibodies
S Yung, TM Chan - Frontiers in immunology, 2015 - frontiersin.org
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by a
breakdown of self-tolerance, production of auto-antibodies and immune-mediated injury …
breakdown of self-tolerance, production of auto-antibodies and immune-mediated injury …
Glomerular Autoimmune Multicomponents of Human Lupus Nephritis In Vivo: α:-Enolase and Annexin AI
Renal targets of autoimmunity in human lupus nephritis (LN) are unknown. We sought to
identify autoantibodies and glomerular target antigens in renal biopsy samples from patients …
identify autoantibodies and glomerular target antigens in renal biopsy samples from patients …
[HTML][HTML] Anti-DNA autoantibodies initiate experimental lupus nephritis by binding directly to the glomerular basement membrane in mice
MR Krishnan, C Wang, TN Marion - Kidney international, 2012 - Elsevier
The strongest serological correlate for lupus nephritis is antibody to double-stranded DNA,
although the mechanism by which anti-DNA antibodies initiate lupus nephritis is unresolved …
although the mechanism by which anti-DNA antibodies initiate lupus nephritis is unresolved …
Pathogenesis of renal disease in systemic lupus erythematosus—the role of autoantibodies and lymphocytes subset abnormalities
DYH Yap, KN Lai - International journal of molecular sciences, 2015 - mdpi.com
Lupus nephritis (LN) is a common and severe organ manifestation of systemic lupus
erythematosus (SLE), and is associated with significant patient morbidity and mortality …
erythematosus (SLE), and is associated with significant patient morbidity and mortality …