Computational models for lncRNA function prediction and functional similarity calculation

X Chen, YZ Sun, NN Guan, J Qu… - Briefings in …, 2019 - academic.oup.com
From transcriptional noise to dark matter of biology, the rapidly changing view of long non-
coding RNA (lncRNA) leads to deep understanding of human complex diseases induced by …

The crosstalk between lncRNA and microRNA in cancer metastasis: orchestrating the epithelial-mesenchymal plasticity

M Cao, Y Jiang, Y Tang, X Liang - Oncotarget, 2016 - pmc.ncbi.nlm.nih.gov
Noncoding RNAs (ncRNAs) have been demonstrated to closely associate with gene
regulation and encompass the well-known microRNAs (miRNAs), as well as the most …

[HTML][HTML] ILNCSIM: improved lncRNA functional similarity calculation model

YA Huang, X Chen, ZH You, DS Huang, KCC Chan - Oncotarget, 2016 - ncbi.nlm.nih.gov
Increasing observations have indicated that lncRNAs play a significant role in various critical
biological processes and the development and progression of various human diseases …

Strategies to annotate and characterize long noncoding RNAs: advantages and pitfalls

H Cao, C Wahlestedt, P Kapranov - Trends in Genetics, 2018 - cell.com
The past decade has seen an explosion of interest in long noncoding RNAs (lncRNAs).
However, despite the massive volume of scientific data implicating these transcripts in a …

Tetracycline-inducible shRNA targeting antisense long non-coding RNA HIF1A-AS2 represses the malignant phenotypes of bladder cancer

M Chen, C Zhuang, Y Liu, J Li, F Dai, M Xia, Y Zhan… - Cancer letters, 2016 - Elsevier
Various studies have indicated that long non-coding RNAs (lncRNAs) play vital roles in the
cancer development and progression. LncRNA hypoxia inducible factor 1alpha antisense …

KCNQ1OT1/miR-217/ZEB1 feedback loop facilitates cell migration and epithelial-mesenchymal transition in colorectal cancer

Y Bian, G Gao, Q Zhang, H Qian, L Yu… - Cancer biology & …, 2019 - Taylor & Francis
Long noncoding RNAs are widely acknowledged as a group of regulatory factors in various
diseases, especially in cancers. KCNQ1 overlapping transcript 1 (KCNQ1OT1) has been …

Alcohol use disorder causes global changes in splicing in the human brain

D Van Booven, M Li, J Sunil Rao, IO Blokhin… - Translational …, 2021 - nature.com
Alcohol use disorder (AUD) is a widespread disease leading to the deterioration of cognitive
and other functions. Mechanisms by which alcohol affects the brain are not fully elucidated …

[HTML][HTML] LncRNA GAS5 contributes to lymphatic metastasis in colorectal cancer

Y Zheng, D Song, K Xiao, C Yang, Y Ding, W Deng… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Colorectal cancer (CRC) ranks the third most common type of cancer worldwide. However,
the detailed molecular mechanisms underlying these processes are poorly understood …

Developments in lncRNA drug discovery: where are we heading?

I Blokhin, O Khorkova, J Hsiao… - Expert opinion on drug …, 2018 - Taylor & Francis
Introduction: The central dogma of molecular biology, which states that the only role of long
RNA transcripts is to convey information from gene to protein, was brought into question in …

LINC 00312 represses proliferation and metastasis of colorectal cancer cells by regulation of miR‐21

G Li, C Wang, Y Wang, B Xu… - Journal of Cellular and …, 2018 - Wiley Online Library
Long non‐coding RNA s (lnc RNA s) have emerged as important regulators of cancer,
including colorectal cancer (CRC). The exact expression pattern of long intergenic …