Cancer the 'RBP'eutics–RNA-binding proteins as therapeutic targets for cancer

S Mohibi, X Chen, J Zhang - Pharmacology & therapeutics, 2019 - Elsevier
RNA-binding proteins (RBPs) play a critical role in the regulation of various RNA processes,
including splicing, cleavage and polyadenylation, transport, translation and degradation of …

Detecting liver cancer using cell-free DNA fragmentomes

ZH Foda, AV Annapragada, K Boyapati, DC Bruhm… - Cancer discovery, 2023 - AACR
Liver cancer is a major cause of cancer mortality worldwide. Screening individuals at high
risk, including those with cirrhosis and viral hepatitis, provides an avenue for improved …

Mineral metabolism and ferroptosis in non-alcoholic fatty liver diseases

C Ma, L Han, Z Zhu, CH Pang, G Pan - Biochemical Pharmacology, 2022 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) has become the most prevalent chronic liver
disease worldwide. Minerals including iron, copper, zinc, and selenium, fulfil an essential …

Dysregulation of RNA splicing in early non-alcoholic fatty liver disease through hepatocellular carcinoma

NJG Webster, D Kumar, P Wu - Scientific Reports, 2024 - nature.com
While changes in RNA splicing have been extensively studied in hepatocellular carcinoma
(HCC), no studies have systematically investigated changes in RNA splicing during earlier …

CD73, tumor plasticity and immune evasion in solid cancers

H Yang, F Yao, PF Davis, ST Tan, SRR Hall - Cancers, 2021 - mdpi.com
Simple Summary Tumors are ecosystems composed of cancer cells and non-tumor stroma
together in a hypoxic environment often described as wounds that do not heal. Accumulating …

[HTML][HTML] Long noncoding RNA (lncRNA) HOTAIR: Pathogenic roles and therapeutic opportunities in gastric cancer

W Kong, G Yin, S Zheng, X Liu, A Zhu, P Yu, J Zhang… - Genes & …, 2022 - Elsevier
Gastric cancer is one of the first malignant cancers in the world and a large number of
people die every year due to this disease. Many genetic and epigenetic risk factors have …

Splicing factor poly (rC)‐binding protein 1 is a novel and distinctive tumor suppressor

J Guo, R Jia - Journal of cellular physiology, 2019 - Wiley Online Library
A lot of evidence has been found on the link between tumorigenesis and the aberrant
expression of splicing factors. A number of splicing factors have been reported to be either …

Combining bulk and single-cell RNA-sequencing data to develop an NK cell-related prognostic signature for hepatocellular carcinoma based on an integrated …

Q Feng, Z Huang, L Song, L Wang, H Lu… - European Journal of …, 2023 - Springer
Background The application of molecular targeting therapy and immunotherapy has notably
prolonged the survival of patients with hepatocellular carcinoma (HCC). However, multidrug …

Impact of alternative splicing variants on liver cancer biology

JJG Marin, M Reviejo, M Soto, E Lozano, M Asensio… - Cancers, 2021 - mdpi.com
Simple Summary Among the top ten deadly solid tumors are the two most frequent liver
cancers, hepatocellular carcinoma, and intrahepatic cholangiocarcinoma, whose …

High expression of P2X7R is an independent postoperative indicator of poor prognosis in colorectal cancer

F Qian, J Xiao, B Hu, N Sun, W Yin, J Zhu - Human pathology, 2017 - Elsevier
The purinergic P2X7 receptor (P2X7R) is a master regulator of inflammation and
inflammation-related diseases. Recently, P2X7R has been reportedly involved in …