Mitochondria are signaling organelles that regulate a wide variety of cellular functions and
can dictate cell fate. Multiple mechanisms contribute to communicate mitochondrial fitness to …

Macrophages are a heterogeneous population of immune cells playing several and diverse
functions in homeostatic and immune responses. The broad spectrum of macrophage …

The NLRP3 inflammasome is linked to sterile and pathogen-dependent inflammation, and
its dysregulation underlies many chronic diseases. Mitochondria have been implicated as …

Itaconate is one of the best examples of the consequences of metabolic reprogramming
during immunity. It is made by diverting aconitate away from the tricarboxylic acid cycle …

Lysosomes are the main organelles in macrophages for killing invading bacteria. However,
the precise mechanism underlying lysosomal biogenesis upon bacterial infection remains …

Metabolic rewiring and epigenetic remodeling, which are closely linked and reciprocally
regulate each other, are among the well-known cancer hallmarks. Recent evidence …

Metabolism in immune cells is no longer thought of as merely a process for adenosine
triphosphate (ATP) production, biosynthesis, and catabolism. The reprogramming of …

Metabolic reprogramming has become a key focus for both immunologists and cancer
biologists, with exciting advances providing new insights into the mechanisms underlying …

Succinate is an important metabolite at the cross-road of several metabolic pathways, also
involved in the formation and elimination of reactive oxygen species. However, it is …

Traditionally cellular respiration or metabolism has been viewed as catabolic and anabolic
pathways generating energy and biosynthetic precursors required for growth and general …