Many of the internal organ systems of Drosophila melanogaster are functionally analogous
to those in vertebrates, including humans. Although humans and flies differ greatly in terms …

Cardiovascular diseases (CVDs) are the major causes of death in the western world. The
incidence of cardiovascular disease as well as the rate of cardiovascular mortality and …

Deep catalogs of genetic variation from thousands of humans enable the detection of
intraspecies constraint by identifying coding regions with a scarcity of variation. While …

Small open reading frames (smORFs) are short DNA sequences that are able to encode
small peptides of less than 100 amino acids. Study of these elements has been neglected …

Sestrins are conserved proteins that accumulate in cells exposed to stress, potentiate
adenosine monophosphate–activated protein kinase (AMPK), and inhibit activation of target …

Summary High-fat-diet (HFD)-induced obesity is a major contributor to diabetes and
cardiovascular disease, but the underlying genetic mechanisms are poorly understood …

The soaring prevalence of obesity and diabetes is associated with an increase in
comorbidities, including elevated risk for cardiovascular diseases (CVDs). CVDs continue to …

Insects are the most ecologically important multicellular heterotrophs in terrestrial systems.
They play critical roles in ecological food webs, remain devastating agricultural and medical …

Diets high in carbohydrates have long been linked to progressive heart dysfunction, yet the
mechanisms by which chronic high sugar leads to heart failure remain poorly understood …

The genetic basis of heart development is remarkably conserved from Drosophila to
mammals, and insights from flies have greatly informed our understanding of vertebrate …