Breast cancer is the most common malignancy in the female population with a high mortality rate. Despite the satisfying depth of studies evaluating the contributory role of immune …
Abstract Indoleamine-2, 3-dioxygenase (IDO1) pathway has vital role in cancer immune escape and its upregulation leads to immunosuppressive environment which is associated …
M Yazdani, M Hatamipour, B Alani… - Iranian journal of …, 2020 - ncbi.nlm.nih.gov
Objective (s): Program death 1 (PD-1)/program death-ligand 1 (PD-L1) pathways, as the main inhibitory checkpoints, induce immunosuppression in the tumor microenvironment …
Background One of the important metabolic pathways in cancer progression is tryptophan catabolism by the indoleamin-2, 3-dioxygenase (IDO) enzyme, which suppresses the …
Background Cancer is still the most challenging disease and is responsible for many deaths worldwide. Considerable research now focuses on targeted therapy in cancer using natural …