Force generation in striated muscle is primarily controlled by structural changes in the actin-
containing thin filaments triggered by an increase in intracellular calcium concentration …

The discovery of the giant protein titin, also known as connectin, dates almost half a century
back. In this review, I recapitulate major advances in the discovery of the titin filaments and …

Skeletal muscle force production is increased at longer compared to shorter muscle lengths
because of length-dependent priming of thick filament proteins in the contractile unit before …

Heart muscle has the unique property that it can never rest; all cardiomyocytes contract with
each heartbeat which requires a complex control mechanism to regulate cardiac output to …

Myocardial passive stiffness is crucial for the heart's pump function and is determined by
mechanical elements, including the extracellular matrix and cytoskeletal filaments; however …

Muscle contraction is produced via the interaction of myofilaments and is regulated so that
muscle performance matches demand. Myosin-binding protein C (MyBP-C) is a long and …

BACKGROUND: Increasing cardiomyocyte contraction during myocardial stretch serves as
the basis for the Frank-Starling mechanism in the heart. However, it remains unclear how …

Muscles generate forces for animal locomotion. The contractile apparatus of muscles is the
sarcomere, a highly regular array of large actin and myosin filaments linked by gigantic titin …

Eccentric muscle loading encompasses several unique features compared to other types of
contractions. These features include increased force, work, and performance at decreased …

Sarcomeres are the force-producing units of all striated muscles. Their nanoarchitecture
critically depends on the large titin protein, which in vertebrates spans from the sarcomeric Z …