Antiretroviral therapy (ART) inhibits HIV replication but is not curative. During ART, the
integrated HIV genome persists indefinitely within CD4+ T cells and perhaps other cells …

One of the most explored therapeutic approaches aimed at eradicating HIV-1 reservoirs is
the “shock and kill” strategy which is based on HIV-1 reactivation in latently-infected cells …

HIV-1 persists indefinitely in people living with HIV (PLWH) on antiretroviral therapy (ART). If
ART is stopped, the virus rapidly rebounds from long-lived latently infected cells. Using a …

Antiretroviral therapy controls HIV replication but does not eliminate the virus from the
infected host. The persistence of a small pool of cells harboring integrated and replication …

Combination antiretroviral therapy (ART) suppresses human immunodeficiency virus (HIV)
replication and improves immune function, but is unable to eradicate the virus. Therefore …

The precise role of CD4 T cell turnover in maintaining HIV persistence during antiretroviral
therapy (ART) has not yet been well characterized. In resting CD4 T cell subpopulations …

Background HIV-1 proviruses can persist during ART in clonally-expanded populations of
CD4+ T cells. To date, few examples of an expanded clones containing replication …

Studies have demonstrated that intensive ART alone is not capable of eradicating HIV-1, as
the virus rebounds within a few weeks upon treatment interruption. Viral rebound may be …

Historically, naive cells have been considered inconsequential to HIV persistence. Here, we
compared the contributions of naive and memory cells to the reservoirs of individuals with a …

Despite the success of highly active antiretroviral therapy (HAART), integrated HIV-1 proviral
DNA cannot be eradicated from an infected individual. HAART is not able to eliminate …