Cleft lip and/or cleft palate (CL/P) collectively are well known as being amongst the most
common birth defects but we still have difficulty explaining why the majority of cases occur …

Abstract Development of the human skull and face is a highly orchestrated and complex
three-dimensional morphogenetic process, involving hundreds of genes controlling the …

Nonsyndromic cleft lip with or without cleft palate (nsCL/P) is among the most common
human birth defects with multifactorial etiology. Here, we present results from a genome …

Prior genome-wide association studies for oral clefts have focused on clinic-based samples
with unclear generalizability. Prior samples were also small for investigating effects by cleft …

Objective: To examine the associations of methionine synthase (MTR), methionine synthase
reductase (MTRR), and methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms …

Genome‐wide association studies (GWAS) for orofacial clefts have identified several
susceptibility regions, but have largely focused on non‐Hispanic White populations in …

In the past decade, medical genetic research has generated multiple discoveries, many of
which were obtained via genome-wide association studies (GWASs). A major GWAS finding …

Orofacial clefts (OFCs) are common, complex birth defects with extremely heterogeneous
phenotypic presentations. Two common subtypes—cleft lip alone (CL) and CL plus cleft …

Nonsyndromic cleft lip with or without cleft palate (NSCL/P) is a common craniofacial birth
defect that has a complex etiology. Genome-wide association studies have recently …

Background: A number of genes are associated with the incidence of non-syndromic cleft
lip/palate (NSCL/P). Studies have shown a significant association between polymorphisms …