Purpose Drug-induced nephrotoxicity is one of the most common side effects of medications
and accounts for about 20% of hospital admissions for acute kidney injury (AKI). Some …

The aim of the current study was to investigate the probable protective effects of
Pentoxifylline (PTX) and Alpha Lipoic Acid (ALA), which display anti-oxidative efficacy …

Objective The restoration of blood flow to the brain after ischemic stroke prevents further,
extensive damage but can result in reperfusion injury. The inflammation response is one of …

Diclofenac, one of the most commonly used non-steroidal anti-inflammatory drugs, leads to
severe adverse effects on the kidneys. The aim of the present study was to investigate the …

We investigated the potential neuroprotective effects of thymoquinone (TQ) on amikacin (AK)
induced oxidative damage in rat brain. We used 21 male rats divided randomly into three …

Amikacin (AMK) is one of the most effective aminoglycoside antibiotics. However,
nephrotoxicity is a major deleterious and dose-limiting side effect associated with its clinical …

We investigated whether thymoquinone (TQ) exerts a beneficial effect on renal injury due to
amikacin (AK) administration in rats. To generate kidney damage with AK, a single 1.2 g/kg …

Herein, the molecular pathogenic pathways implicated in renal injury triggered by amikacin
(AK), together with the alleviating actions of β‐caryophyllene (BCP), were investigated. Adult …

Amikacin (AK) is an aminoglycoside that is widely used to treat life-threatening Gram-
negative infections, especially in intensive care units. Despite its wide clinical indications …

Nitrosamines are well-known carcinogenic agents. Humans are exposed to nitrosamines in
various ways, the most important of which is the diet. Pentoxifylline is a xanthine derivative …