The two β-arrestins, β-arrestin-1 and-2 (systematic names: arrestin-2 and-3, respectively),
are multifunctional intracellular proteins that regulate the activity of a very large number of …

Over the past three years (2020–2022) more structures of GPCRs have been determined
than in the previous twenty years (2000–2019), primarily of GPCR complexes that are large …

Arrestins have pivotal roles in regulating G protein-coupled receptor (GPCR) signalling by
desensitizing G protein activation and mediating receptor internalization,. It has been …

Agonist-induced GPCR phosphorylation is a key determinant for the binding and activation
of β-arrestins (βarrs). However, it is not entirely clear how different GPCRs harboring …

G protein–coupled receptor (GPCR) kinases (GRKs) and arrestins interact with agonist-
bound GPCRs to promote receptor desensitization and downregulation. They also trigger …

Cannabis activates the cannabinoid receptor 1 (CB1), which elicits analgesic and emotion
regulation benefits, along with adverse effects, via G i and β-arrestin signaling pathways …

The two non-visual arrestins, arrestin2 and arrestin3, bind hundreds of GPCRs with different
phosphorylation patterns, leading to distinct functional outcomes. Structural information on …

β-arrestins (βarrs) are multifunctional proteins involved in signaling and regulation of seven
transmembrane receptors (7TMRs), and their interaction is driven primarily by agonist …

G protein-coupled receptors (GPCRs) are versatile and vital proteins involved in a wide
array of physiological processes and responses, such as sensory perception (eg, vision …

G-protein-coupled receptors (GPCRs) are a family of cell surface proteins that can sense a
variety of extracellular stimuli and mediate multiple signaling transduction pathways …