Regeneration refers to regrowth of tissue in the central nervous system. It includes
generation of new neurons, glia, myelin, and synapses, as well as the regaining of essential …

The nematode Caenorhabditis elegans has emerged as an important animal model in
various fields including neurobiology, developmental biology, and genetics. Characteristics …

Several neurological diseases are characterized by the altered activity of one or a few
ubiquitously expressed cell proteins, but it is not known how these normal proteins turn into …

The precise cause of neuronal death in Huntington's disease (HD) is unknown. Although no
single specific protein-protein interaction of mutant huntingtin has emerged as the …

Huntington's disease (HD) is a neurodegenerative disorder caused by an abnormally
elongated polyglutamine (polyQ) tract in the large protein huntingtin (htt). Currently, both the …

At least nine inherited neurodegenerative diseases share a polyglutamine expansion in
their respective disease proteins. These diseases show distinct neuropathological changes …

All cellular compartments are separated from the external environment by a membrane,
which consists of a lipid bilayer. Subcellular structures, including clathrin-coated pits …

Huntington's disease (HD) is a neurodegenerative disorder previously thought to be of
primary neuronal origin, despite ubiquitous expression of mutant huntingtin (mHtt). We …

Huntington's disease (HD) is a devastating autosomal dominant neurodegenerative disease
caused by a CAG trinucleotide repeat expansion encoding an abnormally long …

Huntington's disease (HD) is caused by a polyglutamine expansion in the protein huntingtin.
In its terminal stage, HD is characterized by widespread neuronal death in the neocortex …