Human high-altitude adaptation: forward genetics meets the HIF pathway
AW Bigham, FS Lee - Genes & development, 2014 - genesdev.cshlp.org
Humans have adapted to the chronic hypoxia of high altitude in several locations, and
recent genome-wide studies have indicated a genetic basis. In some populations, genetic …
recent genome-wide studies have indicated a genetic basis. In some populations, genetic …
Measuring high-altitude adaptation
LG Moore - Journal of applied physiology, 2017 - journals.physiology.org
High altitudes (> 8,000 ft or 2,500 m) provide an experiment of nature for measuring
adaptation and the physiological processes involved. Studies conducted over the past~ 25 …
adaptation and the physiological processes involved. Studies conducted over the past~ 25 …
Functional EPAS1/HIF2A missense variant is associated with hematocrit in Andean highlanders
ES Lawrence, W Gu, RJ Bohlender… - Science …, 2024 - science.org
Hypoxia-inducible factor pathway genes are linked to adaptation in both human and
nonhuman highland species. EPAS1, a notable target of hypoxia adaptation, is associated …
nonhuman highland species. EPAS1, a notable target of hypoxia adaptation, is associated …
Genomic architecture of adaptive radiation and hybridization in Alpine whitefish
Adaptive radiations represent some of the most remarkable explosions of diversification
across the tree of life. However, the constraints to rapid diversification and how they are …
across the tree of life. However, the constraints to rapid diversification and how they are …
Ancient Ethiopian genome reveals extensive Eurasian admixture in Eastern Africa
Characterizing genetic diversity in Africa is a crucial step for most analyses reconstructing
the evolutionary history of anatomically modern humans. However, historic migrations from …
the evolutionary history of anatomically modern humans. However, historic migrations from …
Ancient Ethiopian genome reveals extensive Eurasian admixture throughout the African continent.
M Gallego Llorente, E Jones, A Eriksson, V Siska… - 2015 - repository.cam.ac.uk
Characterizing genetic diversity in Africa is a crucial step for most analyses reconstructing
the evolutionary history of anatomically modern humans. However, historic migrations from …
the evolutionary history of anatomically modern humans. However, historic migrations from …
Convergent evolution in human and domesticate adaptation to high-altitude environments
KE Witt, E Huerta-Sánchez - … Transactions of the Royal …, 2019 - royalsocietypublishing.org
Humans and their domestic animals have lived and thrived in high-altitude environments
worldwide for thousands of years. These populations have developed a number of …
worldwide for thousands of years. These populations have developed a number of …
Fruit flies in biomedical research
Many scientists complain that the current funding situation is dire. Indeed, there has been an
overall decline in support in funding for research from the National Institutes of Health and …
overall decline in support in funding for research from the National Institutes of Health and …
Altitude adaptation: a glimpse through various lenses
TS Simonson - High altitude medicine & biology, 2015 - liebertpub.com
Abstract Simonson, Tatum S. Altitude adaptation: A glimpse through various lenses. High Alt
Med Biol 16: 125–137, 2015.—Recent availability of genome-wide data from highland …
Med Biol 16: 125–137, 2015.—Recent availability of genome-wide data from highland …
Human adaptation to high altitude: a review of convergence between genomic and proteomic signatures
Both genomics-and proteomics-based investigations have identified several essential
genes, proteins, and pathways that may facilitate human adaptive genotype/phenotype in a …
genes, proteins, and pathways that may facilitate human adaptive genotype/phenotype in a …