HER3 is a pseudokinase member of the EGFR family having a role in both tumor
progression and drug resistance. Although HER3 was discovered more than 30 years ago …

Breast cancer is the most prevalent type of tumor and the second leading cause of death
due to cancer among women. Although screening methods, diagnosis and therapeutic …

More than half of cancer patients receive radiotherapy as a part of their cancer treatment.
DNA double-strand breaks (DSBs) are considered as the most lethal form of DNA damage …

Macropinocytosis is an important mechanism of internalizing extracellular materials and
dissolved molecules in eukaryotic cells. Macropinocytosis has a dual effect on cancer cells …

Endocytosis mechanisms are one of the methods that cells use to interact with their
environments. Endocytosis mechanisms vary from the clathrin-mediated endocytosis to the …

EGFR tyrosine kinase inhibitors (TKIs) are standard therapy for EGFR-mutant non-small cell
lung cancer (NSCLC); however, these tumours eventually acquire chemoresistance. U3 …

Macropinocytosis has long been known as a primary method for cellular intake of fluid-
phase and membrane-bound bulk cargo. This review seeks to re-examine the latest studies …

An estimated 15–20% of breast cancers overexpress human epidermal growth factor
receptor 2 (HER2/ERBB2/neu). Two small-molecule tyrosine kinase inhibitors (TKIs) …

In glioblastoma (GBM), the most frequent and lethal brain tumor, therapies suppressing
recurrently altered signaling pathways failed to extend survival. However, in patient subsets …

It is well established that the epidermal growth factor (EGF) receptor, receptor tyrosine-
protein kinase erbB-2 (ERBB2)/human EGF receptor 2 (HER2), and, to a lesser extent …