Large skin wounds pose a major clinical challenge. Scarcity of donor site and postsurgical
scarring contribute to the incomplete or partial loss of function and aesthetic concerns in skin …

Scar formation is a common consequence of skin injuries that lead to a wide range of
adverse effects including physical deformities and psychological disorders. Studies …

COVID-19, also known as SARS-CoV-2, is a new emerging zoonotic corona virus of the
SARS (Severe Acute Respiratory Syndrome) and the MERS (Middle East Respiratory …

On the basis of their differential location within the dermis and of discrete changes in gene
and protein expression, two major fibroblast subtypes (papillary and reticular) have …

Epithelial tissues are the most rapidly dividing tissues in the body, holding a natural ability
for renewal and regeneration. This ability is crucial for survival as epithelia are essential to …

An essential element of tissue homeostasis is the response to injuries, cutaneous wound
healing being the most studied example. In the adults, wound healing aims at quickly …

Wound healing is a complex and long-term process consisting of hemostasis, inflammation,
proliferation, and maturation/remodeling. These four stages overlap and influence each …

Standard cell cultures are performed in aqueous media with a low macromolecule
concentration compared to tissue microenvironment. In macromolecular crowding (MMC) …

Fibroblasts produce collagens and other proteins that form the bulk of the extracellular
matrix (ECM) in connective tissues. Emerging data point to functional heterogeneity of …

Abstract Dipeptidyl peptidase‐4 (DPP4) is a multifunctional, transmembrane glycoprotein
present on the cell surface of various tissues. It is present in multiple molecular forms …