Botulinum toxin intervention in cerebral palsy-induced spasticity management: projected and contradictory effects on skeletal muscles

CS Kaya Keles, F Ates - Toxins, 2022 - mdpi.com
Spasticity, following the neurological disorder of cerebral palsy (CP), describes a
pathological condition, the central feature of which is involuntary and prolonged muscle …

[HTML][HTML] Botulinum toxin intervention in cerebral palsy-induced spasticity management: projected and contradictory effects on skeletal muscles

CSK Keles, F Ates - Toxins, 2022 - ncbi.nlm.nih.gov
Spasticity, following the neurological disorder of cerebral palsy (CP), describes a
pathological condition, the central feature of which is involuntary and prolonged muscle …

Beyond neuromuscular activity: botulinum toxin type A exerts direct central action on spinal control of movement

P Šoštarić, M Matić, D Nemanić, ŽL Vasić… - European journal of …, 2024 - Elsevier
Overt muscle activity and impaired spinal locomotor control hampering coordinated
movement is a hallmark of spasticity and movement disorders like dystonia. While botulinum …

The use of botulinum toxin for treatment of spasticity

S Li, GE Francisco - Botulinum Toxin Therapy, 2021 - Springer
Spasticity is one component of the upper motor neuron (UMN) syndrome resulting from a
multitude of neurologic conditions, such as stroke, brain injury, spinal cord injury, multiple …

Relationship between botulinum toxin, spasticity, and pain: a survey of patient perception

A Shaikh, CP Phadke, F Ismail… - Canadian Journal of …, 2016 - cambridge.org
Objective: To assess the prevalence of pain in adults with spasticity and to assess the
association between the subjective experience of pain and spasticity. Design: Cross …

Adverse clinical effects of botulinum toxin intramuscular injections for spasticity

CP Phadke, CK Balasubramanian, A Holz… - Canadian Journal of …, 2016 - cambridge.org
Objective: The adverse events (AEs) with botulinum toxin type-A (BoNTA), used for
indications other than spasticity, are widely reported in the literature. However, the site …

Botulinum toxin injection causes hyper-reflexia and increased muscle stiffness of the triceps surae muscle in the rat

J Pingel, J Wienecke, J Lorentzen… - Journal of …, 2016 - journals.physiology.org
Botulinum toxin is used with the intention of diminishing spasticity and reducing the risk of
development of contractures. Here, we investigated changes in muscle stiffness caused by …

The highest region of muscle spindle abundance should be the optimal target of botulinum toxin A injection to block muscle spasms in rats

J Yu, Y Li, L Yang, Y Li, S Zhang, S Yang - Frontiers in Neurology, 2023 - frontiersin.org
Purpose The effective relief of muscle spasticity requires prompt solutions in rehabilitation
medicine. This study aimed to reveal that the highest region of muscle spindle abundance is …

Impact of passive leg cycling in persons with spinal cord injury: a systematic review

CP Phadke, L Vierira, S Mathur… - Topics in spinal …, 2019 - meridian.allenpress.com
Background: Passive leg cycling is an important clinical tool available for rehabilitation after
spinal cord injury (SCI). Passive cycling can be used to derive exercise-related benefits in …

Intramuscular Botulinum toxin A injections induce central changes to axon initial segments and cholinergic boutons on spinal motoneurones in rats

DB Jensen, S Klingenberg, KP Dimintiyanova… - Scientific reports, 2020 - nature.com
Intramuscular injections of botulinum toxin block pre-synaptic cholinergic release at
neuromuscular junctions producing a temporary paralysis of affected motor units. There is …