The potential of mitochondrial genome engineering

P Silva-Pinheiro, M Minczuk - Nature Reviews Genetics, 2022 - nature.com
Mitochondria are subject to unique genetic control by both nuclear DNA and their own
genome, mitochondrial DNA (mtDNA), of which each mitochondrion contains multiple …

Mitochondrial genome engineering: the revolution may not be CRISPR-Ized

PA Gammage, CT Moraes, M Minczuk - Trends in Genetics, 2018 - cell.com
In recent years mitochondrial DNA (mtDNA) has transitioned to greater prominence across
diverse areas of biology and medicine. The recognition of mitochondria as a major …

Targeted knockout of a conserved plant mitochondrial gene by genome editing

J Forner, D Kleinschmidt, EH Meyer, J Gremmels… - Nature Plants, 2023 - nature.com
Fusion proteins derived from transcription activator-like effectors (TALEs) have emerged as
genome editing tools for mitochondria. TALE nucleases (TALENs) have been applied to …

Second generation biofuels: high-efficiency microalgae for biodiesel production

PM Schenk, SR Thomas-Hall, E Stephens, UC Marx… - Bioenergy …, 2008 - Springer
The use of fossil fuels is now widely accepted as unsustainable due to depleting resources
and the accumulation of greenhouse gases in the environment that have already exceeded …

Targeted base editing in the mitochondrial genome of Arabidopsis thaliana

I Nakazato, M Okuno, C Zhou, T Itoh… - Proceedings of the …, 2022 - National Acad Sciences
Beyond their well-known role in respiration, mitochondria of land plants contain biologically
essential and/or agriculturally important genes whose function and regulation are not fully …

A series of fortunate events: introducing Chlamydomonas as a reference organism

PA Salomé, SS Merchant - The Plant Cell, 2019 - academic.oup.com
The unicellular alga Chlamydomonas reinhardtii is a classical reference organism for
studying photosynthesis, chloroplast biology, cell cycle control, and cilia structure and …

From molecular manipulation of domesticated Chlamydomonas reinhardtii to survival in nature

S Sasso, H Stibor, M Mittag, AR Grossman - elife, 2018 - elifesciences.org
In the mid-20th century, the unicellular and genetically tractable green alga
Chlamydomonas reinhardtii was first developed as a model organism to elucidate …

The emerging role of nanotechnology in plant genetic engineering

HJ Squire, S Tomatz, E Voke… - Nature Reviews …, 2023 - nature.com
Genetic engineering to improve the capabilities of plants is essential given climate change
and population growth pressures. Current manipulation methods are laborious and species …

Generation of Chlamydomonas strains that efficiently express nuclear transgenes

J Neupert, D Karcher, R Bock - The Plant Journal, 2009 - Wiley Online Library
The unicellular green algaChlamydomonas reinhardtii is both an invaluable model
organism for plant biology and an attractive biotechnological production system. Despite the …

Microalgae and cyanobacteria as enzyme biofactories

BSAF Brasil, FG de Siqueira, TFC Salum, CM Zanette… - Algal research, 2017 - Elsevier
Microalgae consist of a diverse group that includes prokaryotic cyanobacteria and
eukaryotic photosynthetic microorganisms that inhabit freshwater and marine habitats …