Pathological angiogenesis: mechanisms and therapeutic strategies

AC Dudley, AW Griffioen - Angiogenesis, 2023 - Springer
In multicellular organisms, angiogenesis, the formation of new blood vessels from pre-
existing ones, is an essential process for growth and development. Different mechanisms …

Endometriosis: Etiology, pathobiology, and therapeutic prospects

PTK Saunders, AW Horne - Cell, 2021 - cell.com
Endometriosis is a common condition associated with infertility that causes chronic pain in
many, but not all, women. It is defined by the presence of endometrial-like tissue outside the …

Hormonal treatments for endometriosis: The endocrine background

S Vannuccini, S Clemenza, M Rossi… - Reviews in Endocrine and …, 2022 - Springer
Endometriosis is a benign uterine disorder characterized by menstrual pain and infertility,
deeply affecting women's health. It is a chronic disease and requires a long term …

Once daily oral relugolix combination therapy versus placebo in patients with endometriosis-associated pain: two replicate phase 3, randomised, double-blind, studies …

LC Giudice, S As-Sanie, JCA Ferreira, CM Becker… - The Lancet, 2022 - thelancet.com
Background Endometriosis is a common cause of pelvic pain in women, for which current
treatment options are suboptimal. Relugolix, an oral gonadotropin-releasing hormone …

Assessing research gaps and unmet needs in endometriosis

S As-Sanie, R Black, LC Giudice, TG Valbrun… - American journal of …, 2019 - Elsevier
Endometriosis, a systemic disease that is often painful and chronic, affects∼ 10% of
reproductive-age women. The disease can have a negative impact on a patient's physical …

New understanding of diagnosis, treatment and prevention of endometriosis

B Amro, ME Ramirez Aristondo, S Alsuwaidi… - International journal of …, 2022 - mdpi.com
For 100 years, pelvic endometriosis has been considered to originate from the implantation
of endometrial cells following retrograde menstruation or metaplasia. Since some …

Endometriosis, an ongoing pain—step-by-step treatment

S Mechsner - Journal of clinical medicine, 2022 - mdpi.com
Endometriosis is a disease that is becoming more and more challenging for the medical
community. The current therapeutic concepts (surgical therapy and/or hormonal therapies) …

Nutrition in the prevention and treatment of endometriosis: A review

ND Barnard, DN Holtz, N Schmidt, S Kolipaka… - Frontiers in …, 2023 - frontiersin.org
Endometriosis is characterized by the presence of endometrial tissues outside the uterine
lining, typically on the external surface of the uterus, the ovaries, fallopian tubes, abdominal …

Chronic niche inflammation in endometriosis-associated infertility: current understanding and future therapeutic strategies

YH Lin, YH Chen, HY Chang, HK Au, CR Tzeng… - International journal of …, 2018 - mdpi.com
Endometriosis is an estrogen-dependent inflammatory disease that affects up to 10% of
women of reproductive age and accounts for up to 50% of female infertility cases. It has …

Medical treatment of endometriosis-related pain

P Vercellini, L Buggio, MP Frattaruolo, A Borghi… - Best Practice & …, 2018 - Elsevier
Available medical treatments for symptomatic endometriosis act by inhibiting ovulation,
reducing serum oestradiol levels, and suppressing uterine blood flows. For this, several …