Force spectroscopy of single cells using atomic force microscopy

A Viljoen, M Mathelié-Guinlet, A Ray… - Nature Reviews …, 2021 - nature.com
Physical forces and mechanical properties have critical roles in cellular function, physiology
and disease. Over the past decade, atomic force microscopy (AFM) techniques have …

Atomic force microscopy-based force spectroscopy and multiparametric imaging of biomolecular and cellular systems

DJ Müller, AC Dumitru, C Lo Giudice… - Chemical …, 2020 - ACS Publications
During the last three decades, a series of key technological improvements turned atomic
force microscopy (AFM) into a nanoscopic laboratory to directly observe and chemically …

Molecular interaction and inhibition of SARS-CoV-2 binding to the ACE2 receptor

J Yang, SJL Petitjean, M Koehler, Q Zhang… - Nature …, 2020 - nature.com
Study of the interactions established between the viral glycoproteins and their host receptors
is of critical importance for a better understanding of virus entry into cells. The novel …

Multivalent 9-O-Acetylated-sialic acid glycoclusters as potent inhibitors for SARS-CoV-2 infection

SJL Petitjean, W Chen, M Koehler, R Jimmidi… - Nature …, 2022 - nature.com
The recent emergence of highly transmissible SARS-CoV-2 variants illustrates the urgent
need to better understand the molecular details of the virus binding to its host cell and to …

Surface chemistry can unlock drivers of surface stability of SARS-CoV-2 in a variety of environmental conditions

E Joonaki, A Hassanpouryouzband, CL Heldt, O Areo - Chem, 2020 - cell.com
The surface stability and resulting transmission of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), specifically in indoor environments, have been identified as a …

Molecular insights into receptor binding energetics and neutralization of SARS-CoV-2 variants

M Koehler, A Ray, RA Moreira, B Juniku… - Nature …, 2021 - nature.com
Despite an unprecedented global gain in knowledge since the emergence of SARS-CoV-2,
almost all mechanistic knowledge related to the molecular and cellular details of viral …

Virus interactions with bacteria: Partners in the infectious dance

U Neu, BA Mainou - PLoS Pathogens, 2020 - journals.plos.org
The outcome of viral infection depends on the interplay between host factors and the
environment. Host factors, like the expression of viral receptors, convey permissiveness to …

Initial step of virus entry: virion binding to cell-surface glycans

M Koehler, M Delguste, C Sieben, L Gillet… - Annual review of …, 2020 - annualreviews.org
Virus infection is an intricate process that requires the concerted action of both viral and host
cell components. Entry of viruses into cells is initiated by interactions between viral proteins …

Enhancing cancer therapy: the integration of oncolytic virus therapy with diverse treatments

Z Yan, Z Zhang, Y Chen, J Xu, J Wang, Z Wang - Cancer Cell International, 2024 - Springer
As one of the significant challenges to human health, cancer has long been a focal point in
medical treatment. With ongoing advancements in the field of medicine, numerous …

Genetic manipulation of human intestinal enteroids demonstrates the necessity of a functional fucosyltransferase 2 gene for secretor-dependent human norovirus …

K Haga, K Ettayebi, VR Tenge, UC Karandikar… - MBio, 2020 - Am Soc Microbiol
Human noroviruses (HuNoVs) are the leading cause of nonbacterial gastroenteritis
worldwide. Histo-blood group antigen (HBGA) expression is an important susceptibility …