Allosteric modulation of family C G-protein-coupled receptors: from molecular insights to therapeutic perspectives
S Urwyler, DR Sibley - Pharmacological reviews, 2011 - Elsevier
Allosteric receptor modulation is an attractive concept in drug targeting because it offers
important potential advantages over conventional orthosteric agonism or antagonism …
important potential advantages over conventional orthosteric agonism or antagonism …
Group II metabotropic glutamate receptor agonists and positive allosteric modulators as novel treatments for schizophrenia
MJ Fell, DL McKinzie, JA Monn, KA Svensson - Neuropharmacology, 2012 - Elsevier
Schizophrenia is a devastating chronic psychotic disorder characterized by positive,
negative, and cognitive symptoms. Although the positive symptoms are relatively well …
negative, and cognitive symptoms. Although the positive symptoms are relatively well …
Bimetallic aluminum (salen) catalyzed synthesis of oxazolidinones from epoxides and isocyanates
T Baronsky, C Beattie, RW Harrington, R Irfan… - ACS …, 2013 - ACS Publications
The bimetallic aluminum (salen) complex [Al (salen)] 2O is shown to catalyze the synthesis
of oxazolidinones from epoxides and isocyanates. The reaction is demonstrated to proceed …
of oxazolidinones from epoxides and isocyanates. The reaction is demonstrated to proceed …
Synthesis of oxazolidinones from epoxides and isocyanates catalyzed by rare‐earth‐metal complexes
P Wang, J Qin, D Yuan, Y Wang, Y Yao - ChemCatChem, 2015 - Wiley Online Library
Rare‐earth‐metal complexes stabilized by an amino‐bridged triphenolate ligand showed
high efficiency in catalyzing the cycloaddition of isocyanates and epoxides in the presence …
high efficiency in catalyzing the cycloaddition of isocyanates and epoxides in the presence …
Efficient methods for the synthesis of chiral 2‐oxazolidinones as pharmaceutical building blocks
K Okuno, R Nishiyori, K Abe, T Mori, S Shirakawa - Chirality, 2022 - Wiley Online Library
Although the wide variety of heterocyclic compounds is common knowledge, chiral 2‐
oxazolidinones are recognized as some of the most important heterocycles in medicinal …
oxazolidinones are recognized as some of the most important heterocycles in medicinal …
Oxazolidinone derivatives: Cytoxazone–Linezolid hybrids induces apoptosis and senescence in DU145 prostate cancer cells
A Naresh, MV Rao, SS Kotapalli, R Ummanni… - European Journal of …, 2014 - Elsevier
In this study, we report the synthesis of novel oxazolidinone derivatives derived from
linezolid 3 having p-methoxyphenyl group at C-4 position. In vitro evaluation for their …
linezolid 3 having p-methoxyphenyl group at C-4 position. In vitro evaluation for their …
5-(Carbamoylmethylene)-oxazolidin-2-ones as a promising class of heterocycles inducing apoptosis triggered by increased ros levels and mitochondrial dysfunction …
Oxazolidinones are antibiotics that inhibit protein synthesis by binding the 50S ribosomal
subunit. Recently, numerous worldwide researches focused on their properties and possible …
subunit. Recently, numerous worldwide researches focused on their properties and possible …
Actions of Xanthurenic acid, a putative endogenous Group II metabotropic glutamate receptor agonist, on sensory transmission in the thalamus
CS Copeland, SA Neale, TE Salt - Neuropharmacology, 2013 - Elsevier
Xanthurenic acid (XA), a molecule arising from tryptophan metabolism by transamination of
3-hydroxykynurenine, has recently been identified as an endogenous Group II (mGlu2 and …
3-hydroxykynurenine, has recently been identified as an endogenous Group II (mGlu2 and …
Metabotropic glutamate receptors for new treatments in schizophrenia
Metabotropic glutamate receptors (mGluRs) represent exciting targets for the development
of novel therapeutic agents for schizophrenia. Recent studies indicate that selective …
of novel therapeutic agents for schizophrenia. Recent studies indicate that selective …
Recent advances in the exploration of oxazolidinone scaffolds from compound development to antibacterial agents and other bioactivities
M Ampomah-Wireko, S Chen, R Li, C Gao… - European Journal of …, 2024 - Elsevier
Bacterial infections cause a variety of life-threatening diseases, and the continuous
evolution of drug-resistant bacteria poses an increasing threat to current antimicrobial …
evolution of drug-resistant bacteria poses an increasing threat to current antimicrobial …