COVID-19: a global challenge with old history, epidemiology and progress so far
Humans have witnessed three deadly pandemics so far in the twenty-first century which are
associated with novel coronaviruses: SARS, Middle East respiratory syndrome (MERS), and …
associated with novel coronaviruses: SARS, Middle East respiratory syndrome (MERS), and …
Where should siRNAs go: applicable organs for siRNA drugs
I Ahn, CS Kang, J Han - Experimental & Molecular Medicine, 2023 - nature.com
RNA interference mediated by small interfering RNAs (siRNAs) has been exploited for the
development of therapeutics. siRNAs can be a powerful therapeutic tool because the …
development of therapeutics. siRNAs can be a powerful therapeutic tool because the …
Nucleic acid delivery for therapeutic applications
Recent medical advances have exploited the ability to address a given disease at the
underlying level of transcription and translation. These treatment paradigms utilize nucleic …
underlying level of transcription and translation. These treatment paradigms utilize nucleic …
The potential of siRNA based drug delivery in respiratory disorders: Recent advances and progress
Lung diseases are the leading cause of mortality worldwide. The currently available
therapies are not sufficient, leading to the urgent need for new therapies with sustained anti …
therapies are not sufficient, leading to the urgent need for new therapies with sustained anti …
Recent advances in siRNA delivery mediated by lipid-based nanoparticles
S Yonezawa, H Koide, T Asai - Advanced drug delivery reviews, 2020 - Elsevier
Small interfering RNA (siRNA) has been expected to be a unique pharmaceutic for the
treatment of broad-spectrum intractable diseases. However, its unfavorable properties such …
treatment of broad-spectrum intractable diseases. However, its unfavorable properties such …
The uniqueness of tryptophan in biology: properties, metabolism, interactions and localization in proteins
S Barik - International journal of molecular sciences, 2020 - mdpi.com
Tryptophan (Trp) holds a unique place in biology for a multitude of reasons. It is the largest
of all twenty amino acids in the translational toolbox. Its side chain is indole, which is …
of all twenty amino acids in the translational toolbox. Its side chain is indole, which is …
Knocking down barriers: advances in siRNA delivery
In the 10 years that have passed since the Nobel prize-winning discovery of RNA
interference (RNAi), billions of dollars have been invested in the therapeutic application of …
interference (RNAi), billions of dollars have been invested in the therapeutic application of …
Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application
AL Jackson, PS Linsley - Nature reviews Drug discovery, 2010 - nature.com
Small interfering RNAs (siRNAs) are widely used to study gene function owing to the ease
with which they silence target genes, and there is considerable interest in their potential for …
with which they silence target genes, and there is considerable interest in their potential for …
Lipid-like materials for low-dose, in vivo gene silencing
KT Love, KP Mahon, CG Levins… - Proceedings of the …, 2010 - National Acad Sciences
Significant effort has been applied to discover and develop vehicles which can guide small
interfering RNAs (siRNA) through the many barriers guarding the interior of target cells …
interfering RNAs (siRNA) through the many barriers guarding the interior of target cells …
Silencing of SARS‐CoV‐2 with modified siRNA‐peptide dendrimer formulation
Background First vaccines for prevention of Coronavirus disease 2019 (COVID‐19) are
becoming available but there is a huge and unmet need for specific forms of treatment. In …
becoming available but there is a huge and unmet need for specific forms of treatment. In …