Endocrine disrupting chemicals: exposure, effects on human health, mechanism of action, models for testing and strategies for prevention

B Yilmaz, H Terekeci, S Sandal… - Reviews in endocrine and …, 2020 - Springer
Abstract Endocrine Disrupting Chemicals (EDCs) are a global problem for environmental
and human health. They are defined as “an exogenous chemical, or mixture of chemicals …

Temporal trends in sperm count: a systematic review and meta-regression analysis

H Levine, N Jørgensen… - Human reproduction …, 2017 - academic.oup.com
BACKGROUND Reported declines in sperm counts remain controversial today and recent
trends are unknown. A definitive meta-analysis is critical given the predictive value of sperm …

Human exposure to endocrine disrupting chemicals: effects on the male and female reproductive systems

S Sifakis, VP Androutsopoulos, AM Tsatsakis… - Environmental …, 2017 - Elsevier
Endocrine disrupting chemicals (EDCs) comprise a group of chemical compounds that have
been examined extensively due to the potential harmful effects in the health of human …

Current knowledge on endocrine disrupting chemicals (EDCs) from animal biology to humans, from pregnancy to adulthood: highlights from a national Italian meeting

ME Street, S Angelini, S Bernasconi, E Burgio… - International journal of …, 2018 - mdpi.com
Wildlife has often presented and suggested the effects of endocrine disrupting chemicals
(EDCs). Animal studies have given us an important opportunity to understand the …

The environment and male reproduction: The effect of cadmium exposure on reproductive function and its implication in fertility

C De Angelis, M Galdiero, C Pivonello, C Salzano… - Reproductive …, 2017 - Elsevier
Cadmium is an environmental pollutant known as endocrine disruptor. Testis is particularly
susceptible to cadmium, and testis injury occurs at high but even low levels of exposure …

Metabolic regulation is important for spermatogenesis

L Rato, MG Alves, S Socorro, AI Duarte… - Nature Reviews …, 2012 - nature.com
Male factor infertility is increasing in developed countries, and several factors linked to
lifestyle have been shown to negatively affect spermatogenesis. Sertoli cells are pivotal to …

Smoke, alcohol and drug addiction and male fertility

A Sansone, C Di Dato, C de Angelis, D Menafra… - Reproductive biology …, 2018 - Springer
In recent decades, the decline in human fertility has become increasingly more worrying:
while therapeutic interventions might help, they are vexing for the couple and often …

Exploring the role of gut microbiome in male reproduction

Y Wang, Z Xie - Andrology, 2022 - Wiley Online Library
Background The impact of the gut microbiome on the organism has become a growing
research focus with the development of 16S rRNA sequencing. However, the effect of the gut …

Toxicological effects of cadmium on mammalian testis

Q Zhu, X Li, RS Ge - Frontiers in genetics, 2020 - frontiersin.org
Cadmium is a heavy metal, and people are exposed to it through contaminated foods and
smoking. In humans and other mammals, cadmium causes damage to male testis. In this …

Cadmium attenuates testosterone synthesis by promoting ferroptosis and blocking autophagosome-lysosome fusion

L Zeng, J Zhou, X Wang, Y Zhang, M Wang… - Free Radical Biology and …, 2021 - Elsevier
Ferroptosis is a newly defined programmed cell death pathway characterized by iron
overload and lipid peroxidation. Increasing studies show that autophagy regulates …