The cascade of amyloid formation relates to multiple complex events at the molecular level.
Previous research has established amyloid plaque deposition as the leading cause of …

The accumulation of the amyloid‐β peptides (Aβ) is central to the development of
Alzheimer's disease. The mechanism by which Aβ triggers a cascade of events that leads to …

Exosome analysis is a promising tool for clinical and biological research applications.
However, detection and biomarker quantification of exosomes is technically challenging …

Central to Alzheimer's disease (AD) is the assembly of the amyloid‐beta peptide (Aβ) into
fibrils. A reduction in pH accompanying inflammation or subcellular compartments, may …

In this work, we investigate how fluid flows impact the aggregation mechanisms of Aβ40
proteins and Aβ16–22 peptides and mechanically perturb their (pre) fibrillar aggregates. We …

Perturbation of cell membranes by amyloid β (Ab) peptide oligomers is one possible
mechanism of cytotoxicity in Alzheimer's disease, but the structure of such Ab–membrane …

In various domains spanning materials synthesis, chemical catalysis, life sciences, and
energy materials, in situ transmission electron microscopy (TEM) methods exert a profound …

Alzheimer's disease (AD) is highly associated with self-aggregation of amyloid β (Aβ)
proteins into fibrils. Inhibition of Aβ aggregation by polyphenols is one of the major …

Alzheimer's disease (AD) is linked with the self-association of the amyloid-β peptide (Aβ)
into oligomers and fibrils. The brain is a lipid rich environment for Aβ to assemble, while the …

Amyloid-beta (Aβ1–42) aggregation triggers neurotoxicity and is linked to Alzheimer's
disease. Aβ1–42 oligomers, rather than extended fibrils, adhere to the cell membrane …