The smooth muscle cell directly drives the contraction of the vascular wall and hence
regulates the size of the blood vessel lumen. We review here the current understanding of …

Epidemiological research over the last 50 years has discovered a plethora of biomarkers
(including molecules, traits or other diseases) that associate with coronary artery disease …

Background: High blood pressure (BP) is a major risk factor for cardiovascular diseases
(CVDs), the leading cause of mortality worldwide. Both heritable and lifestyle risk factors …

Although genetic risk scores have been used to predict hypertension, their utility in the
clinical setting remains uncertain. Our study comprised N= 218 792 FinnGen participants …

Cardiometabolic diseases contribute more to global morbidity and mortality than any other
group of disorders. Polygenic risk scores (PRSs), the weighted summation of individually …

Recent advances in genome-wide association studies have stimulated interest in the
genomic prediction of disease risk, potentially enabling individual-level risk estimates for …

A history of hypertension has been associated with increased risk of endometrial cancer in
several studies, but the results have not been consistent. We conducted a systematic review …

Cardiometabolic diseases are the leading cause of death worldwide and are strongly linked
to both genetic and nutritional factors. The field of nutrigenomics encompasses multiple …

Essential hypertension is a common, complex disorder affecting≤ 1 billion adults globally.
Blood pressure is a highly heritable trait, with≤ 50% of the variation between individuals …

Cardiovascular and renal diseases are associated with many risk factors, of which
hypertension is one of the most prevalent. Worldwide, blood pressure control is only …