Exercise training enhances physical performance and confers health benefits, largely
through adaptations in skeletal muscle. Mitochondrial adaptation, encompassing …

The RSK (90 kDa ribosomal S6 kinase) family comprises a group of highly related
serine/threonine kinases that regulate diverse cellular processes, including cell growth …

Interferons (IFN s) are produced in response to virus infection and induce an antiviral state in
virtually all cell types. In addition to upregulating the transcription of genes that inhibit virus …

For decades, type I IFNs have been considered indispensable and unique antiviral
mediators for the activation of rapid innate antiviral protection. However, the recent discovery …

Interferons (IFNs) are generally considered antiviral cytokines, yet the newly discovered IFN-
λ4 is linked with the failure to clear hepatitis C virus (HCV) infection either spontaneously or …

IFNs are cytokines with important antiproliferative activity and exhibit key roles in immune
surveillance against malignancies. Early work initiated over three decades ago led to the …

The 90 kDa ribosomal S6 kinases (RSK) are effectors of the Ras-ERK1/2 signaling pathway.
RSK signaling controls proliferation and protein synthesis, and is altered in several types of …

It is well established that activation of the transcription factor signal transducer and activator
of transcription 1 (STAT1) is required for the interferon-γ (IFN-γ)–mediated antiviral …

Interferons (IFNs) are released by cells on exposure to various stimuli, including viruses,
double-stranded RNA, and other cytokines and various polypeptides. These IFNs play …

Type-I interferon (IFN)-induced activation of the mammalian target of rapamycin (mTOR)
signaling pathway has been implicated in translational control of mRNAs encoding …