The physiological functions of sphingosine 1-phosphate (S1P) and its pathological roles in
various diseases are increasingly being elucidated. Particularly, a growing body of literature …

Neuropsychiatric and neurological disorders pose a significant global health burden,
highlighting the need for innovative therapeutic approaches. Fingolimod (FTY720), a …

Abstract Sphingosine-1-phosphate (S1P) plays important roles as a signaling lipid in a
variety of physiological and pathophysiological processes. S1P signals via a family of G …

Stress can promote the development of psychiatric disorders, though some individuals are
more vulnerable to stress compared to others who are more resilient. Here we show that the …

Pain is a clinical condition that is currently of great concern and is often caused by tissue or
nerve damage or occurs as a concomitant symptom of a variety of diseases such as cancer …

Chronic pain is a life-altering condition affecting millions of people. Current treatments are
inadequate and prolonged therapies come with severe side effects, especially dependence …

Somatosensory neurons mediate responses to diverse mechanical stimuli, from innocuous
touch to noxious pain. While recent studies have identified distinct populations of A …

Microglial fatty-acid binding protein 4 (FABP4) is a regulator of neuroinflammation. We
hypothesized that the link between lipid metabolism and inflammation indicates a role for …

Background Prenatal depressive symptoms (PDS) is a serious public health problem. This
study aimed to develop an integrated panel and nomogram to assess at-risk populations by …

Obesity is considered a risk factor for type 2 diabetes mellitus, which has become one of the
most important health problems, and is also linked with memory and executive function …