Manipulating bacterial communities by in situ microbiome engineering

RU Sheth, V Cabral, SP Chen, HH Wang - Trends in Genetics, 2016 - cell.com
Microbial communities inhabit our entire planet and have a crucial role in biogeochemical
processes, agriculture, biotechnology, and human health. Here, we argue that 'in situ …

Better together: engineering and application of microbial symbioses

SG Hays, WG Patrick, M Ziesack, N Oxman… - Current opinion in …, 2015 - Elsevier
Highlights•Microbial communities are naturally abundant.•Natural symbioses exhibit
increased robustness and metabolic capabilities.•Technological advances in environmental …

Metagenomic engineering of the mammalian gut microbiome in situ

C Ronda, SP Chen, V Cabral, SJ Yaung, HH Wang - Nature methods, 2019 - nature.com
Engineering of microbial communities in open environments remains challenging. Here we
describe a platform used to identify and modify genetically tractable mammalian microbiota …

Use of 16S rRNA gene-targeted group-specific primers for real-time PCR analysis of predominant bacteria in mouse feces

YW Yang, MK Chen, BY Yang, XJ Huang… - Applied and …, 2015 - Am Soc Microbiol
Mouse models are widely used for studying gastrointestinal (GI) tract-related diseases. It is
necessary and important to develop a new set of primers to monitor the mouse gut …

Synthetic biology approaches to engineer probiotics and members of the human microbiota for biomedical applications

JR Bober, CL Beisel, NU Nair - Annual review of biomedical …, 2018 - annualreviews.org
An increasing number of studies have strongly correlated the composition of the human
microbiota with many human health conditions and, in several cases, have shown that …

Escherichia coli as a model organism and its application in biotechnology

VMN Idalia, F Bernardo - … . Biotechnol. Appl. Tech Open Rij. Croat, 2017 - books.google.com
Without a doubt, in the past 20 or so years, we have achieved the power of biology in
different ways. In the present, we have many tools for developing novel technologies and …

Modernized tools for streamlined genetic manipulation and comparative study of wild and diverse proteobacterial lineages

TJ Wiles, ES Wall, BH Schlomann, EA Hay… - MBio, 2018 - Am Soc Microbiol
Correlating the presence of bacteria and the genes they carry with aspects of plant and
animal biology is rapidly outpacing the functional characterization of naturally occurring …

Grand challenges in space synthetic biology

AA Menezes, MG Montague… - Journal of The …, 2015 - royalsocietypublishing.org
Space synthetic biology is a branch of biotechnology dedicated to engineering biological
systems for space exploration, industry and science. There is significant public and private …

On the origins and control of community types in the human microbiome

TE Gibson, A Bashan, HT Cao… - PLoS computational …, 2016 - journals.plos.org
Microbiome-based stratification of healthy individuals into compositional categories, referred
to as “enterotypes” or “community types”, holds promise for drastically improving …

Dietary geraniol by oral or enema administration strongly reduces dysbiosis and systemic inflammation in dextran sulfate sodium-treated mice

L De Fazio, E Spisni, E Cavazza, A Strillacci… - Frontiers in …, 2016 - frontiersin.org
(Trans)-3, 7-Dimethyl-2, 6-octadien-1-ol, commonly called geraniol (Ge-OH), is an acyclic
monoterpene alcohol with well-known anti-inflammatory, antitumoral, and antimicrobial …