Transition metals such as copper are essential for many physiological processes yet can be
toxic at elevated levels. Other metals (eg lead) are nonessential and potentially highly toxic …

Oh what a difference a decade makes! In a landmark paper published in 1996, Feder and
colleagues identified the long-sought gene mutated in patients with classical hereditary …

Ethylene regulates plant growth, development, and responsiveness to a variety of stresses.
Cloning of the Arabidopsis EIN2 gene identifies a central component of the ethylene …

Although disorders of iron metabolism are prevalent, iron transport remains poorly
understood. To address this problem, we undertook a positional cloning strategy to identify …

The family of NRAMP metal ion transporters functions in diverse organisms from bacteria to
human. NRAMP1 functions in metal transport across the phagosomal membrane of …

Nramp genes code for a widely distributed class of proteins involved in a variety of
processes, ranging from the control of susceptibility to bacterial infection in mammalian cells …

Disorders that perturb iron balance are among the most prevalent human diseases, but until
recently iron transport remained poorly understood. Over the past five years, genetic studies …

The NRAMP family of divalent-metal transporters plays a key role in the homeostasis of iron
and other metals. NRAMP2 (DMT1) acts as an iron-uptake protein in both the duodenum …

The Nramp1 (natural-resistance-associated macrophage protein 1) locus (Bcg, Ity, Lsh)
controls the innate resistance or susceptibility of mice to infection with a group of unrelated …

The innate immune system of vertebrates was considered as a survival of ancient
antimicrobial systems that have become obsolescent by the emergence of adaptive …