Chronic pain conditions are multifactorial disorders with a high frequency in the population.
Their pathophysiology is often unclear, and treatment is inefficient. During the last 20 years …

Chronic headache is particularly prevalent in migraineurs and it can progress to a condition
known as medication overuse headache (MOH). MOH is a secondary headache caused by …

Background and purpose Erenumab (ERE) is the first anticalcitonin gene‐related peptide
receptor monoclonal antibody approved for migraine prevention. A proportion of patients do …

Objective To summarize the pharmacology of the calcitonin peptide family of receptors and
explore their relationship to migraine and current migraine therapies. Background …

Primary headache disorders (PHD), specifically migraine, are strongly associated with
temporomandibular disorders (TMD), sharing some patterns of orofacial pain. Both disorders …

Background Research imaging of brain structure and function has helped to elucidate the
pathophysiology of medication overuse headache (MOH). Methods This is a narrative …

Cluster headache (CH) is a severe primary headache with a prevalence of 1/1000
individuals, and a predominance in men. Calcitonin gene-related peptide (CGRP) is a …

Migraine is the most disabling and expensive chronic disorders, the etiology of which is still
not fully known. The neuronal systems,(glutammatergic, dopaminergic, serotoninergic and …

Purpose of review Medication-overuse headache is a secondary chronic headache
disorder, evolving from an episodic primary headache type, caused by the frequent and …

Background the interest of clinical reaseach in polymorphisms and epigenetics in migraine
has been growing over the years. Due to the new era of preventative migraine treatment …