Effective management of breast cancer depends on early diagnosis and proper monitoring
of patients' response to therapy. However, these goals are difficult to achieve because of the …

MicroRNAs (miRNAs) are endogenous 22 nt non-coding RNAs that target mRNAs for
cleavage or translational repression. Numerous miRNAs regulate programmed cell death …

Transcription factors are regulatory proteins that either activate or repress the transcription of
genes via binding to DNA regulatory sequences and regulating recruitment of transcriptional …

The discovery of miRNAs as important regulatory agents for gene expression has expanded
the therapeutic opportunities for oligonucleotides. In contrast to siRNA, miRNA-targeted …

The transition from ductal carcinoma in situ to invasive ductal carcinoma is a key event in
breast cancer progression that is still not well understood. To discover the microRNAs …

MicroRNAs (miRNAs) negatively and post-transcriptionally regulate expression of multiple
target genes to support anabolic pathways for bone formation. Here, we show that miR-218 …

Background Osteoarthritis (OA) is one of the most common rheumatic diseases of which
clinical symptoms includes swelling, synovitis and inflammatory pain, affect patients' daily …

The Slit family is a family of secreted proteins that play important roles in various physiologic
and pathologic activities via interacting with Robo receptors. Slit/Robo signaling was first …

Several microRNAs have been implicated in human breast cancer but none to date have
been validated or utilized consistently in clinical management. MicroRNA-301 (miR-301) …

MicroRNAs (miRNAs) are small endogenous non-coding molecules that alters gene
expression through post-transcriptional regulation of messenger RNA. Compelling evidence …