Importance Platform trials have become increasingly common, and evidence is needed to
determine how this trial design is actually applied in current research practice. Objective To …

Background: Phase 3 clinical trials for disease-modifying therapies in relapsing-remitting
multiple sclerosis (RRMS) have utilized a limited number of conventional designs with a …

Background Advances in precision oncology led to approval of tumour-agnostic molecularly
guided treatment options (MGTOs). The minimum requirements for claiming tumour-agnostic …

Abstract Background State of the Science (SoS) meetings are used to define and highlight
important unanswered scientific questions. The National Heart, Lung, and Blood Institute …

Clinical trials have been the bedrock of research to evaluate the safety and efficacy of new
medical, surgical, or other interventions. Traditional “explanatory” clinical trials have aimed …

In this paper, the case study of ketamine as a new treatment for severe depression is used to
outline the challenges of repurposing established medicines and we suggest potential …

Objectives: This study aimed to conduct a bibliometric analysis of research on endometriosis
and infertility, focusing on the 100 most-cited (TOP100) articles in the literature. Design: The …

Abstract Background Neurofibromatosis type 1, NF2-related schwannomatosis and non-NF2-
related schwannomatosis (grouped under the abbreviation “NF”) are rare hereditary tumor …

Background Globally, there is a growing focus on efficient trials, yet numerous
interpretations have emerged, suggesting a significant heterogeneity in understanding …

As durable learning research systems, adaptive platform trials represent a transformative
new approach to accelerating clinical evaluation and discovery in critical care. This …