CYP51, a monooxygenase associated with the sterol synthesis pathway, is responsible for
the catalysis of the 14-methyl hydroxylation reaction of lanosterol precursors. This enzyme is …

Antifungal drugs and antifungal agrochemicals have significant limitations. These include
several unintended consequences of their use including the growing importance of intrinsic …

Substantial morbidity and mortality of fungal infections have aroused concerns all over the
world, and common Candida spp. currently bring about severe systemic infections. A series …

Dual-target (CYP51/PD-L1) plays an important role in the process of fungal proliferation and
immune suppression. A series of novel quinazoline compounds with dual-target inhibition …

In this study, PD-L1 and CYP51 were selected as key dual-target enzymes, which play an
important role in the process of fungal proliferation and immune suppression. A series of …

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV2), which caused novel
corona virus disease-2019 (COVID-19) pandemic, necessitated a global demand for studies …

A series of imidazole and triazole diarylpyrazole derivatives were prepared using an efficient
5-step synthetic scheme and evaluated for binding affinity with Mycobacterium tuberculosis …

One in every eight women will be diagnosed with breast cancer during their lifetime and
approximately 70% of all patients are oestrogen receptor (ER) positive depending upon …

A series of 2-aryl-3-azolyl-1-indolyl-propan-2-ols was designed as new analogs of
fluconazole (FLC) by replacing one of its two triazole moieties by an indole scaffold. Two …

Novel Quinoline‐triazole hybrid derivatives (9 a–9 l) were designed and synthesized via
click reaction methodology to develop lead compounds with good antibacterial and …