Histones serve to both package and organize DNA within the nucleus. In addition to histone
post-translational modification and chromatin remodelling complexes, histone variants …

Kinetochores are large protein assemblies that connect chromosomes to microtubules of the
mitotic and meiotic spindles in order to distribute the replicated genome from a mother cell to …

The association of histones with specific chaperone complexes is important for their folding,
oligomerization, post-translational modification, nuclear import, stability, assembly and …

The centromere is the region of the chromosome that directs its segregation in mitosis and
meiosis. Although the functional importance of the centromere has been appreciated for …

Histones package and compact DNA by assembling into nucleosome core particles. Most
histones are synthesized at S phase for rapid deposition behind replication forks. In addition …

Nucleosome assembly following DNA replication, DNA repair and gene transcription is
critical for the maintenance of genome stability and epigenetic information. Nucleosomes …

A critical requirement for mitosis is the distribution of genetic material to the two daughter
cells. The central player in this process is the macromolecular kinetochore structure, which …

Stability and function of eukaryotic genomes are closely linked to chromatin structure and
organization. During cell division the entire genome must be accurately replicated and the …

A multitude of histone chaperones are required to support histones from their biosynthesis
until DNA deposition. They cooperate through the formation of histone co-chaperone …

Chromosome segregation during mitosis requires assembly of the kinetochore complex at
the centromere. Kinetochore assembly depends on specific recognition of the histone …