The heart is the most metabolically flexible organ with respect to the use of substrates
available in different states of energy metabolism. Cardiac mitochondria sense substrate …

It is puzzling that hydrogen-rich fatty acids are used only poorly as fuel in the brain. The long-
standing belief that a slow passage of fatty acids across the blood–brain barrier might be the …

Mitochondria are essential for numerous cellular processes, yet hundreds of their proteins
lack robust functional annotation. To reveal functions for these proteins (termed MXPs), we …

It has long been recognized that energy metabolism is linked to the production of reactive
oxygen species (ROS) and critical enzymes allied to metabolic pathways can be affected by …

Mitochondria play a central role in the production of reactive oxygen species as byproducts
of metabolism and energy production. In order to protect cellular structures from oxidative …

Electron transfer flavoprotein (ETF) is an enzyme with orthologs from bacteria to humans.
Human ETF is nuclear encoded by two separate genes, ETFA and ETFB, respectively. After …

H2O2 production by skeletal muscle mitochondria oxidizing palmitoylcarnitine was
examined under two conditions: the absence of respiratory chain inhibitors and the …

Aging is associated with a decline in mitochondrial function which may contribute to age-
related diseases such as neurodegeneration, cancer, and cardiovascular diseases …

The kidney has extraordinary metabolic demands to sustain the active transport of solutes
that is critical to renal filtration and clearance. Mitochondrial health is vital to meet those …

Mitochondrial reactive oxygen species (ROS) are widely implicated in physiological and
pathological pathways. We propose that it is critical to understand the specific sites of …