The metabolically hostile tumour microenvironment imposes barriers to tumour-infiltrating
immune cells and impedes durable clinical remission following immunotherapy. Metabolic …

Tumour-associated macrophages (TAMs) are crucial components of the tumour
microenvironment and play a significant role in tumour development and drug resistance by …

In vitro studies have associated oxidative phosphorylation (OXPHOS) with anti-inflammatory
macrophages, whereas pro-inflammatory macrophages rely on glycolysis. However, the …

Exposure of lipopolysaccharide triggers macrophage pro-inflammatory polarization
accompanied by metabolic reprogramming, characterized by elevated aerobic glycolysis …

Metazoan tissue specification is associated with integration of macrophage lineage cells in
sub-tissular niches to promote tissue development and homeostasis. Oncogenic …

Initiating and maintaining optimal immune responses requires high levels of protein
synthesis, folding, modification and trafficking in leukocytes, which are processes …

Macrophages are one of the most important cells in the innate immune system, they are
converted into two distinct subtypes with completely different molecular phenotypes and …

The tumor microenvironment (TME) provokes endoplasmic reticulum (ER) stress in
malignant cells and infiltrating immune populations. Sensing and responding to ER stress is …

Macrophages are highly plastic in different tissues and can differentiate into functional
subpopulations under different stimuli. Tumor-associated macrophages (TAMs) are one of …

Macrophage polarization is influenced by lipids, which also exert significant control over
macrophage functions. Lipids and their metabolites are players in intricate signaling …