Myeloid-derived suppressor cells in the era of increasing myeloid cell diversity
Myeloid-derived suppressor cells (MDSCs) are pathologically activated neutrophils and
monocytes with potent immunosuppressive activity. They are implicated in the regulation of …
monocytes with potent immunosuppressive activity. They are implicated in the regulation of …
Myeloid-derived suppressor cells coming of age
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells
generated during a large array of pathologic conditions ranging from cancer to obesity …
generated during a large array of pathologic conditions ranging from cancer to obesity …
The expression profiles and regulation of PD-L1 in tumor-induced myeloid-derived suppressor cells
ABSTRACT Programmed death-ligand 1 (PD-L1) is an inhibitory ligand that binds to PD-1 to
suppress T cell activation. PD-L1 is constitutively expressed and inducible in tumor cells, but …
suppress T cell activation. PD-L1 is constitutively expressed and inducible in tumor cells, but …
Interleukin-10 produced by myeloid-derived suppressor cells is critical for the induction of Tregs and attenuation of rheumatoid inflammation in mice
Myeloid-derived suppressor cells (MDSCs) are heterogenous populations of immature
myeloid progenitor cells with immunoregulatory function. MDSCs play critical roles in …
myeloid progenitor cells with immunoregulatory function. MDSCs play critical roles in …
Activation of immunosuppressive network in the aging process
A Salminen - Ageing research reviews, 2020 - Elsevier
Chronic low-grade inflammation has a key role in the aging process, a state called
inflammaging. It is known that the chronic inflammatory condition generates counteracting …
inflammaging. It is known that the chronic inflammatory condition generates counteracting …
Mechanisms of immune suppression by myeloid-derived suppressor cells: the role of interleukin-10 as a key immunoregulatory cytokine
Chronic immune activation and inflammation are unwanted consequences of many
pathological conditions, since they could lead to tissue damage and immune exhaustion …
pathological conditions, since they could lead to tissue damage and immune exhaustion …
Immunosenescence: the potential role of myeloid-derived suppressor cells (MDSC) in age-related immune deficiency
A Salminen, K Kaarniranta, A Kauppinen - Cellular and Molecular Life …, 2019 - Springer
The aging process is associated with chronic low-grade inflammation in both humans and
rodents, commonly called inflammaging. At the same time, there is a gradual decline in the …
rodents, commonly called inflammaging. At the same time, there is a gradual decline in the …
Macrophage migration inhibitory factor drives pathology in a mouse model of spondyloarthritis and is associated with human disease
Spondyloarthritis (SpA), a type 3 immunity-mediated inflammatory arthritis, is a systemic
rheumatic disease that primarily affects the joints, spine, gut, skin, and eyes. Macrophage …
rheumatic disease that primarily affects the joints, spine, gut, skin, and eyes. Macrophage …
Arginase-1–dependent promotion of TH17 differentiation and disease progression by MDSCs in systemic lupus erythematosus
Expansion of myeloid-derived suppressor cells (MDSCs) has been documented in some
murine models and patients with autoimmune diseases, but the exact role of MDSCs in this …
murine models and patients with autoimmune diseases, but the exact role of MDSCs in this …
Myeloid-derived suppressor cells: ductile targets in disease
FM Consonni, C Porta, A Marino, C Pandolfo… - Frontiers in …, 2019 - frontiersin.org
Myeloid-derived suppressor cells (MDSCs) represent a heterogeneous population of
immature myeloid cells with major regulatory functions and rise during pathological …
immature myeloid cells with major regulatory functions and rise during pathological …