Metabolic syndrome (MetS) forms a cluster of metabolic dysregulations including insulin
resistance, atherogenic dyslipidemia, central obesity, and hypertension. The pathogenesis …

There are numerous extra-and intra-cellular processes involved in the production of reactive
oxygen species (ROS). Augmented ROS generation can cause the damage of biomolecules …

Atherosclerosis is a chronic inflammatory disease associated with cardiovascular
dysfunction including myocardial infarction, unstable angina, sudden cardiac death, stroke …

Significance: Reactive oxygen species (ROS) play a critical role in vascular disease. While
there are many possible sources of ROS, nicotinamide adenine dinucleotide phosphate …

At high concentrations, free radicals and radical-derived, nonradical reactive species are
hazardous for living organisms and damage all major cellular constituents. At moderate …

Rationale: The function of Nox4, a source of vascular H2O2, is unknown. Other Nox proteins
were identified as mediators of endothelial dysfunction. Objective: We determined the …

Reactive oxygen species (ROS) are generated as by-products of cellular metabolism,
primarily in the mitochondria. When cellular production of ROS overwhelms its antioxidant …

Hydrogen peroxide (H2O2) produced by cell-surface NADPH Oxidase (Nox) enzymes is
emerging as an important signaling molecule for growth, differentiation, and migration …

This review focuses on the role of oxidative processes in atherosclerosis and its resultant
cardiovascular events. There is now a consensus that atherosclerosis represents a state of …

The renin-angiotensin system is a central component of the physiological and pathological
responses of cardiovascular system. Its primary effector hormone, angiotensin II (ANG II), not …