Airway epithelial cells and immune cells participate in the inflammatory process responsible
for much of the pathology found in the lung of patients with cystic fibrosis (CF). Intense …

Microaspiration, or silent aspiration, is commonly suspected in patients with refractory
respiratory symptoms, including unexplained chronic cough, asthma, chronic obstructive …

Although destructive airway disease is evident in young children with cystic fibrosis (CF),
little is known about the nature of the early CF lung environment triggering the disease. To …

Objective Current diagnostic methods for gastro-oesophageal reflux disease (GORD) have
moderate sensitivity/specificity and can be invasive and expensive. Pepsin detection in …

Gastro-oesophageal reflux is associated with a wide range of respiratory disorders,
including asthma, isolated chronic cough, idiopathic pulmonary fibrosis, chronic obstructive …

Airway disease in cystic fibrosis (CF) is characterised by impaired mucociliary clearance,
persistent bacterial infection and neutrophilic inflammation. Lipoxin A4 (LXA4) initiates the …

Background Microaspiration is often considered a potential cause of cough. The aim of this
study was to investigate the relationship between microaspiration, the degree and type of …

Background Up to 80% of patients with cystic fibrosis (CF) may have increased
gastroesophageal reflux and aspiration of duodenogastric contents into the lungs. We aimed …

Progress continues to be made in our understanding of pepsin-mediated damage with
implications for novel therapeutic strategies. Salivary pepsin diagnostics continue to garner …

Background and objective The aims of this observational study were (i) to examine the
prevalence of symptomatic and clinically silent proximal and distal gastro‐oesophageal …