Candida species, in particular C. albicans, represent a major threat to immunocompromised
patients. Able to exist as a commensal on mucosal surfaces of healthy individuals, these …

Candida albicans is a species of fungus that typically resides in the gastrointestinal tracts of
humans and other warm-blooded animals. It is also the most common human fungal …

Cytolytic proteins and peptide toxins are classical virulence factors of several bacterial
pathogens which disrupt epithelial barrier function, damage cells and activate or modulate …

ABSTRACT pH homeostasis is critical for all organisms; in the fungal pathogen Candida
albicans, pH adaptation is critical for virulence in distinct host niches. We demonstrate that …

Candida albicans frequently causes superficial infections by invading and damaging
epithelial cells, but may also cause systemic infections by penetrating through epithelial …

We have characterized CaNrg1 from Candida albicans, the major fungal pathogen in
humans. CaNrg1 contains a zinc finger domain that is conserved in transcriptional …

Candida albicans frequently causes superficial infections by invading and damaging
epithelial cells, but may also cause systemic infections by penetrating through epithelial …

Life-threatening systemic infections often occur due to the translocation of pathogens across
the gut barrier and into the bloodstream. While the microbial and host mechanisms …

Survival in blood and escape from blood vessels into tissues are essential steps for the
yeast Candida albicans to cause systemic infections. To elucidate the influence of blood …

The ability of pathogenic microorganisms to assimilate essential nutrients from their hosts is
critical for pathogenesis. Here we report endothelial zinc sequestration by the major human …