State-of-the-art tissue-clearing methods provide subcellular-level optical access to intact
tissues from individual organs and even to some entire mammals. When combined with light …

Transformative technologies are enabling the construction of three-dimensional maps of
tissues with unprecedented spatial and molecular resolution. Over the next seven years, the …

Recent large-scale collaborations are generating major surveys of cell types and
connections in the mouse brain, collecting large amounts of data across modalities, spatial …

The mammalian brain relies on neurochemistry to fulfill its functions. Yet, the complexity of
the brain metabolome and its changes during diseases or aging remain poorly understood …

The process of cardiac morphogenesis in humans is incompletely understood. Its full
characterization requires a deep exploration of the organ-wide orchestration of gene …

There is increased appreciation that dopamine neurons in the midbrain respond not only to
reward and reward-predicting cues,, but also to other variables such as the distance to …

Spatial transcriptomics (ST) technologies are revolutionizing the way to explore the spatial
architecture of tissues. Currently, ST data analysis is often restricted to a single two …

The mammalian brain contains many specialized cells that develop from a thin sheet of
neuroepithelial progenitor cells. Single-cell transcriptomics revealed hundreds of …

Brain maps are essential for integrating information and interpreting the structure-function
relationship of circuits and behavior. We aimed to generate a systematic classification of the …

The prefrontal cortex (PFC) is a complex brain region that regulates diverse functions
ranging from cognition, emotion and executive action to even pain processing. To decode …