A plethora of studies indicate the important role of cAMP and cGMP cascades in neuronal
plasticity and memory function. As a result, altered cyclic nucleotide signaling has been …

Soluble Guanylate Cyclase (sGC) is the intracellular receptor of Nitric Oxide (NO). The
activation of sGC results in the conversion of Guanosine Triphosphate (GTP) to the …

Soluble guanylate cyclase (sGC) and its product, cyclic guanosine monophosphate, play a
role in learning and memory formation. Zagociguat (CY6463) is a novel stimulator of sGC …

Vascular cognitive impairment (VCI) describes neurodegenerative disorders characterized
by a vascular component. Pathologically, it involves decreased cerebral blood flow (CBF) …

Background: Alzheimer's disease (AD) is a neurodegenerative disorder caused by a
complex interplay of various factors. However, a satisfactory cure for AD remains elusive …

Soluble guanylate cyclase (sGC) requires a heme-group bound in order to produce cGMP, a
second messenger involved in memory formation, while heme-free sGC is inactive. Two …

Vascular cognitive impairment (VCI) is characterized by impairments in cerebral blood flow
(CBF), endothelial function and blood–brain barrier (BBB) integrity. These processes are all …

Aim. To assess memory improvement and neuroprotective and antioxidant effects of
Mitragyna inermis (M. inermis) leaf decoction on the central nervous system. Methodology …

Cyclic guanosine-3′, 5′-monophosphate, better known as cyclic-GMP or cGMP, is a
classical second messenger involved in a variety of intracellular pathways ultimately …

The aim of this study is to present the available and verified methods of prevention of
cognitive decline in healthy older adults and to review clinical trials of therapies to improve …