Carriers of genetic material are divided into vectors of viral and non-viral origin. Viral carriers
are already successfully used in experimental gene therapies, but despite advantages such …

Dendritic polymers (dendrimers and hyperbranched polymers) are becoming increasingly
popular due to their vast range of uses. Due to their distinctive and novel qualities, they have …

Here, we aimed to chemically modify PAMAM dendrimers using lysine as a site-selective
anchor for successfully delivering mRNA while maintaining a low toxicity profile. PAMAM …

During the last decades, the use of nanotechnology in medicine has effectively been
translated to the design of drug delivery systems, nanostructured tissues, diagnostic …

Polyamidoamines (PAMAMs) are a class of dendrimer with monodispersity and controlled
topology, which can deliver biologically active macromolecules (eg, genes and proteins) to …

Mesenchymal stem cells (MSCs) have recently emerged as a promising living carrier for
targeted drug delivery. A wealth of literature has shown evidence for great advances in …

Nanomedicine 2.0 refers to the next generation of nanotechnology-based medical therapies
and diagnostic tools. This field focuses on the development of more sophisticated and …

The research and development of non-viral gene therapy has been extensive over the past
decade and has received a big push thanks to the recent successful approval of non-viral …

Nucleic acids represent a promising lead for engineering the immune system. However,
naked DNA, mRNA, siRNA, and other nucleic acids are prone to enzymatic degradation and …

Purpose Lipoparticles are the core-shell type lipid-polymer hybrid systems comprising
polymeric nanoparticle core enveloped by single or multiple pegylated lipid layers (shell) …