Infections with protozoa parasites are associated with high burdens of morbidity and
mortality across the developing world. Despite extensive efforts to control the transmission of …

Treatment of many infectious diseases is under threat from drug resistance. Understanding
the mechanisms of resistance is as high a priority as the development of new drugs. We …

The ABC (ATP-binding cassette) protein superfamily is a ubiquitous and functionally
versatile family of proteins that is conserved from archaea to humans. In eukaryotes, most of …

Ivermectin is widely used in human and veterinary medicine for the control of helminth
infections. Ivermectin is known to interact with P-glycoprotein (P-gp/MDR1), being a good …

Trichomonas vaginalis is the causative agent of trichomoniasis, one of the most common
sexually transmitted diseases in humans. This protozoan has multiple proteinases that are …

Group II metabotropic glutamate receptor (mGluR) agonists have emerged as potential
treatment drugs for schizophrenia and other neurological disorders, whereas the …

Many azole-resistant (AR) clinical isolates of Candida albicans display increased
expression of the drug transporters CDR1 and CDR2. In this study, we evaluate the …

Using genetically matched azole-susceptible (AS) and azole-resistant (AR) clinical isolates
of Candida albicans, we recently demonstrated that CDR1 overexpression in AR isolates is …

Background In eukaryotic and prokaryotic cells, homologous recombination is an accurate
mechanism to generate genetic diversity, and it is also used to repair DNA double strand …

The Entamoeba histolytica transcription factor Upstream Regulatory Element 3-Binding
Protein (URE3-BP) is a calcium-responsive regulator of two E. histolytica virulence genes …