Aging and oocyte competence: A molecular cell perspective

AF Ferreira, M Soares… - WIREs Mechanisms …, 2023 - Wiley Online Library
Follicular microenvironment is paramount in the acquisition of oocyte competence, which is
dependent on two interconnected and interdependent processes: nuclear and cytoplasmic …

Female age and parity in horses: how and why does it matter?

E Derisoud, J Auclair-Ronzaud, E Palmer… - Reproduction …, 2021 - CSIRO Publishing
Although puberty can occur as early as 14–15months of age, depending on breed and use,
the reproductive career of mares may continue to advanced ages. Once mares are used as …

Equine maternal aging affects the metabolomic profile of oocytes and follicular cells during different maturation time points

GD Catandi, DR Bresnahan, SO Peters… - Frontiers in Cell and …, 2023 - frontiersin.org
Introduction: Oocyte quality and fertility decline with advanced maternal age. During
maturation within the ovarian follicle, the oocyte relies on the associated somatic cells …

Oocyte metabolic function, lipid composition, and developmental potential are altered by diet in older mares

GD Catandi, L LiPuma, YM Obeidat… - …, 2022 - rep.bioscientifica.com
Dietary supplementation is the most feasible method to improve oocyte function and
developmental potential in vivo. During three experiments, oocytes were collected from …

Cryopreservation of equine spermatozoa reduces plasma membrane integrity and phospholipase C zeta 1 content as associated with oocyte activation

RA Gonzalez‐Castro, LA Whitcomb, EC Pinsinski… - …, 2024 - Wiley Online Library
Abstract Background Phospholipase C zeta (PLCZ1) is considered the major sperm‐borne
oocyte activation factor. Cryopreserved stallion spermatozoa are commonly used for …

[HTML][HTML] Cloning horses by somatic cell nuclear transfer: Effects of oocyte source on development to foaling

JV Cortez, K Hardwicke, J Cuervo-Arango, CG Grupen - Theriogenology, 2023 - Elsevier
The cloning of horses is a commercial reality, yet the availability of oocytes for cloned
embryo production remains a major limitation. Immature oocytes collected from abattoir …

[HTML][HTML] Multiomics insights into the female reproductive aging

S Wei, W Tang, D Chen, J Xiong, L Xue, Y Dai… - Ageing Research …, 2024 - Elsevier
The human female reproductive lifespan significantly diminishes with age, leading to
decreased fertility, reduced fertility quality and endocrine function disorders. While many …

Follicular metabolic alterations are associated with obesity in mares and can be mitigated by dietary supplementation

GD Catandi, KJ Fresa, MH Cheng, LA Whitcomb… - Scientific reports, 2024 - nature.com
Obesity is a growing concern in human and equine populations, predisposing to metabolic
pathologies and reproductive disturbances. Cellular lipid accumulation and mitochondrial …

Mapping the lipidomic secretome of the early equine embryo

EF Lawson, R Pickford, RJ Aitken, Z Gibb… - Frontiers in Veterinary …, 2024 - frontiersin.org
The lipidomic secretions of embryos provide a unique opportunity to examine the cellular
processes of the early conceptus. In this study we profiled lipids released by the early …

Maturation and culture affect the metabolomic profile of oocytes and follicular cells in young and old mares

DR Bresnahan, GD Catandi, SO Peters… - Frontiers in Cell and …, 2024 - frontiersin.org
Introduction: Oocytes and follicular somatic cells within the ovarian follicle are altered during
maturation and after exposure to culture in vitro. In the present study, we used a nontargeted …