Treatment strategies for cryptococcal infection: challenges, advances and future outlook
Cryptococcus spp., in particular Cryptococcus neoformans and Cryptococcus gattii, have an
enormous impact on human health worldwide. The global burden of cryptococcal meningitis …
enormous impact on human health worldwide. The global burden of cryptococcal meningitis …
A neglected epidemic: fungal infections in HIV/AIDS
Invasive fungal infections (IFIs) are a major cause of HIV-related mortality globally. Despite
widespread rollout of combined antiretroviral therapy, there are still up to 1 million deaths …
widespread rollout of combined antiretroviral therapy, there are still up to 1 million deaths …
Induction of memory-like dendritic cell responses in vivo
Dendritic cells (DCs), a vital component of the innate immune system, are considered to lack
antigen specificity and be devoid of immunological memory. Strategies that can induce …
antigen specificity and be devoid of immunological memory. Strategies that can induce …
Pathogenic fungal infection in the lung
Z Li, G Lu, G Meng - Frontiers in immunology, 2019 - frontiersin.org
Respiratory fungal infection is a severe clinical problem, especially in patients with
compromised immune functions. Aspergillus, Cryptococcus, Pneumocystis, and endemic …
compromised immune functions. Aspergillus, Cryptococcus, Pneumocystis, and endemic …
Trojan horse transit contributes to blood-brain barrier crossing of a eukaryotic pathogen
The blood-brain barrier (BBB) protects the central nervous system (CNS) by restricting the
passage of molecules and microorganisms. Despite this barrier, however, the fungal …
passage of molecules and microorganisms. Despite this barrier, however, the fungal …
Cerebrospinal fluid cytokine profiles predict risk of early mortality and immune reconstitution inflammatory syndrome in HIV-associated cryptococcal meningitis
Understanding the host immune response during cryptococcal meningitis (CM) is of critical
importance for the development of immunomodulatory therapies. We profiled the …
importance for the development of immunomodulatory therapies. We profiled the …
[HTML][HTML] Classical versus alternative macrophage activation: the Ying and the Yang in host defense against pulmonary fungal infections
CML Wager, FL Wormley Jr - Mucosal immunology, 2014 - Elsevier
Macrophages are innate immune cells that possess unique abilities to polarize toward
different phenotypes. Classically activated macrophages are known to have major roles in …
different phenotypes. Classically activated macrophages are known to have major roles in …
CD4+ T Cells Orchestrate Lethal Immune Pathology despite Fungal Clearance during Cryptococcus neoformans Meningoencephalitis
Cryptococcus neoformans is a major fungal pathogen that disseminates to the central
nervous system (CNS) to cause fatal meningoencephalitis, but little is known about immune …
nervous system (CNS) to cause fatal meningoencephalitis, but little is known about immune …
The Phenotype of the Cryptococcus-Specific CD4+ Memory T-Cell Response Is Associated With Disease Severity and Outcome in HIV-Associated Cryptococcal …
JN Jarvis, JP Casazza, HH Stone… - The Journal of …, 2013 - academic.oup.com
Background. Correlates of immune protection in patients with human immunodeficiency
virus (HIV)–associated cryptococcal meningitis are poorly defined. A clearer understanding …
virus (HIV)–associated cryptococcal meningitis are poorly defined. A clearer understanding …
Cryptococcus and Phagocytes: Complex Interactions that Influence Disease Outcome
Cryptococcus neoformans and C. gattii are fungal pathogens that cause life-threatening
disease. These fungi commonly enter their host via inhalation into the lungs where they …
disease. These fungi commonly enter their host via inhalation into the lungs where they …