Varespladib in the treatment of snakebite envenoming: development history and preclinical evidence supporting advancement to clinical trials in patients bitten by …

MR Lewin, RW Carter, IA Matteo, SP Samuel, S Rao… - Toxins, 2022 - mdpi.com
The availability of effective, reliably accessible, and affordable treatments for snakebite
envenoming is a critical and long unmet medical need. Recently, small, synthetic toxin …

Case fatality rate and burden of snakebite envenoming in children–A systematic review and meta-analysis

G Iliyasu, FM Dayyab, GC Michael, M Hamza… - Toxicon, 2023 - Elsevier
Snakebite is a major public health problem with an estimated global burden of 5 million
people per annum. Data on snakebite envenoming in children are very limited and is …

The BRAVO clinical study protocol: oral varespladib for inhibition of secretory phospholipase A2 in the treatment of snakebite envenoming

RW Carter, CJ Gerardo, SP Samuel, S Kumar… - toxins, 2022 - mdpi.com
Introduction: Snakebite is an urgent, unmet global medical need causing significant
morbidity and mortality worldwide. Varespladib is a potent inhibitor of venom secretory …

Photobiomodulation Therapy to Treat Snakebites Caused by Bothrops atrox: A Randomized Clinical Trial

É da Silva Carvalho… - JAMA Internal …, 2024 - jamanetwork.com
Importance Bothropsvenom acts almost immediately at the bite site and causes tissue
damage. Objective To investigate the feasibility and explore the safety and efficacy of low …

Injuries and medical emergencies among international travellers

M Potin, PN Carron, B Genton - Journal of travel medicine, 2024 - academic.oup.com
Background Tropical infectious diseases and vaccine-preventable emergencies are the
mainstay of pre-travel consultations. However, non-communicable diseases, injuries and …

Snakebite envenoming in Brazilian children: Clinical aspects, management and outcomes

IS Oliveira, MB Pucca, FA Cerni, S Vieira… - Journal of tropical …, 2023 - academic.oup.com
Snakebite envenoming is currently considered a neglected tropical disease, which affects
over 5 million people worldwide, and causes almost 150 000 deaths every year, as well as …

A mechanistic model of snakebite as a zoonosis: Envenoming incidence is driven by snake ecology, socioeconomics and its impacts on snakes

G Martín, JJ Erinjery, D Ediriweera… - PLoS neglected …, 2022 - journals.plos.org
Snakebite is the only WHO-listed, not infectious neglected tropical disease (NTD), although
its eco-epidemiology is similar to that of zoonotic infections: envenoming occurs after a …

Oral varespladib for the treatment of snakebite envenoming in India and the USA (BRAVO): a phase II randomised clinical trial

CJ Gerardo, RW Carter, S Kumar, FM Shirazi… - BMJ Global …, 2024 - gh.bmj.com
Introduction Snakebite envenoming (SBE) results in over 500 000 deaths or disabling
injuries annually. Varespladib methyl, an oral inhibitor of secretory phospholipase A2, is a …

Epidemiology of fatal snakebites in the United States 1989–2018

SC Greene, J Folt, K Wyatt, NP Brandehoff - The American journal of …, 2021 - Elsevier
Abstract Background There are 5000–10,000 snake envenomations annually in the United
States. Fortunately, few are fatal. In this study we review the epidemiology of fatal …

[HTML][HTML] Snakebite envenomation in children: An ongoing burden in Morocco

M Essafti, M Fajri, C Rahmani, S Abdelaziz… - Annals of Medicine and …, 2022 - Elsevier
Introduction Snakebites are a leading cause of mortality and permanent disabilities
especially among children in tropical countries and rural areas such as Morocco. Thus, a …